Impact of exercise on brain function in breast cancer patients undergoing chemotherapy
Cardiorespiratory Fitness, Inflammatory Biomarkers, and Cognitive Function Patterns During Treatment for Breast Cancer: a Prospective Cohort Study
This study is trying to see if being physically fit helps breast cancer patients think better during and after chemotherapy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | University of Toronto Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT04616300 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between cardiorespiratory fitness (CRF) and cognitive function in breast cancer patients before and after chemotherapy. It will involve a prospective cohort of 50 women who will be assessed for cognitive abilities, physical activity levels, and cancer biomarkers at baseline and three months post-chemotherapy. The study hypothesizes that higher CRF at baseline will correlate with improved cognitive outcomes, specifically in attention, executive function, and memory. Additionally, it will investigate how lifestyle factors and biological markers influence cognitive decline in this population.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-65 with histologically-confirmed stage I-III breast cancer who have not yet started chemotherapy.
Not a fit: Patients who have received neoadjuvant chemotherapy or are scheduled for concurrent radiation therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cognitive outcomes for breast cancer patients undergoing chemotherapy through targeted lifestyle interventions.
How similar studies have performed: While there is growing evidence on the impact of lifestyle factors on cancer outcomes, this specific approach examining CRF and cognitive function in breast cancer patients undergoing chemotherapy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-65 years old * histologically-confirmed stage I-III breast cancer, but prior to the initiation of chemotherapy (\<1 cycle of adjuvant therapy or neoadjuvant therapy) * no diagnosed major cognitive disorders and uncontrolled comorbidities. Exclusion Criteria: * received neoadjuvant chemotherapy and scheduled to receive adjuvant chemotherapy * scheduled to receive concurrent radiation therapy with chemotherapy.
Where this trial is running
Toronto, Ontario
- Sunnybrook Health Sciences Centre-Odette Cancer Centre — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Linda Trinh, PhD
- Email: linda.trinh@utoronto.ca
- Phone: (416) 946-3624
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.