Impact of exercise on brain function in breast cancer patients undergoing chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between cardiorespiratory fitness (CRF) and cognitive function in breast cancer patients before and after chemotherapy. It will involve a prospective cohort of 50 women who will be assessed for cognitive abilities, physical activity levels, and cancer biomarkers at baseline and three months post-chemotherapy. The study hypothesizes that higher CRF at baseline will correlate with improved cognitive outcomes, specifically in attention, executive function, and memory. Additionally, it will investigate how lifestyle factors and biological markers influence cognitive decline in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-65 years old
* histologically-confirmed stage I-III breast cancer, but prior to the initiation of chemotherapy (\<1 cycle of adjuvant therapy or neoadjuvant therapy)
* no diagnosed major cognitive disorders and uncontrolled comorbidities.

Exclusion Criteria:

* received neoadjuvant chemotherapy and scheduled to receive adjuvant chemotherapy
* scheduled to receive concurrent radiation therapy with chemotherapy.

Where it's running

• Sunnybrook Health Sciences Centre-Odette Cancer Centre
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Linda Trinh, PhD
• Email: linda.trinh@utoronto.ca
• Phone: (416) 946-3624

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.