Sponsor or institution
Clinical trials and research at University of Texas Hlth Ctr at Tyler
As of November 12, 2026, Find a Trial lists 31 NIH-funded research projects at this institution, with $12.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 31NIH research projects
NIH-funded research (31)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Lipid damage and a form of cell death that turns on blood clotting
This grant explores how certain lipid byproducts and inflammatory cell death trigger tissue factor to start dangerous blood clots, with the aim of finding targets to prevent clot-related heart and vessel problems.
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Targeting Runx3 to treat a serious immune disease in children
A new approach aims to help kids with a dangerous immune condition by targeting Runx3 to calm overactive immune cells.
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Southwest Center for Agricultural Health, Injury Prevention, and Education
A regional center partner network is working to improve safety and health for agricultural workers and their communities through research, outreach, and translation of best practices.
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Understanding how coronavirus spike proteins change shape to enter cells
A study to better understand how spike proteins on enveloped viruses change shape over time to help viruses enter cells and how antibodies recognize them.
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Targeting inflammation and clot breakdown to boost empyema treatment
A patient-focused study tests a low-dose alteplase plus an inflammation-blocking peptide to improve drainage and survival for adults with empyema who can’t undergo surgery.
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Gab2-MALT1 signaling and venous clots: a new path to safer therapies
A doctor-scientist team is studying how a specific cell signaling pathway (Gab2-MALT1) contributes to venous clots, with the aim of finding safer ways to prevent and treat them.
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DOCK2 and scarring of the lung lining (pleural fibrosis)
This work looks at whether the protein DOCK2 helps drive scarring of the lung lining in people with pleural fibrosis.
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Tiny particles from the clotting protein FVIIa that help stop bleeding and calm inflammation
This research looks at whether tiny particles released by the clotting protein FVIIa can help stop bleeding and reduce inflammation for people with bleeding disorders or vascular injury.
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RUNX3 and changes in artery walls
This project looks at whether changing the RUNX3 protein can stop artery wall cells from turning into an overgrown, disease-causing state in adults with artery disease or after angioplasty.
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CSP7 helps protect lungs from radiation damage in cancer therapy
A small NIH-funded project tests whether CSP7 can reduce lung injury caused by radiation therapy in cancer patients.
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Shorter, safer drug combinations for Mycobacterium avium lung disease
This project tests new and repurposed antibiotic combinations to shorten and improve treatment for people with Mycobacterium avium complex (MAC) lung infections.
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How HIV's envelope protein shifts shape to enter human cells
Researchers will track how the HIV surface protein changes shape over time to better understand how the virus fuses with and enters human cells.
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Improving agricultural health and safety education
This study is all about making farms safer by teaching workers how to avoid injuries and stay healthy, so if you work in agriculture, this could help you and your coworkers stay safe on the job!
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How virus spike proteins change shape to enter cells
Scientists are looking at how the spike proteins on viruses like SARS‑CoV‑2 change shape to help the virus enter human cells, which could guide better vaccines and treatments.
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Investigating how specific cell signaling affects blood clot formation
This study is looking into how inflammation causes blood clots in conditions like deep vein thrombosis and pulmonary embolism, with the hope of finding new ways to treat these issues safely and effectively, so patients can have better options with less risk of bleeding.
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Investigating how a specific protein affects immune responses to influenza infection
This study is looking at how a protein called Runx3 helps the immune system fight off the flu virus in the lungs, using special mice without this protein to see how it affects their immune response, which could lead to better ways to boost our defenses against respiratory viruses.
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Investigating the role of Factor VIIa-released extracellular vesicles in blood clotting and inflammation
This study is looking at how a protein called Factor VIIa works with other proteins to help control bleeding and inflammation, and it hopes to find new ways to treat bleeding disorders by exploring tiny particles released from blood vessel cells that carry important signals.
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Investigating the role of DOCK2 in lung scarring
This study is looking at pleural fibrosis, a condition that causes scarring in the lungs, and aims to learn how certain cells and a protein called DOCK2 contribute to this problem, with the hope of finding new ways to help people with this condition breathe easier.
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Understanding why some patients struggle with exercise despite having normal heart function.
This study is looking at why some people at risk for heart failure have trouble exercising and doing everyday activities, especially as they get older, and it aims to find ways to help them feel better and move more easily.
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Investigating the role of RUNX3 in blood vessel remodeling
This study is looking at how certain cells in your blood vessels change when they grow too much, which can cause problems like heart disease and high blood pressure, and it will explore the role of a specific protein called RUNX3 to find new ways to help treat these conditions.
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New treatment options for Mycobacterium avium lung disease
This study is looking for better and quicker ways to treat lung infections caused by Mycobacterium avium complex (MAC) by testing different combinations of antibiotics, so patients can get healthier faster with less time on medication.
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Understanding how HIV-1 enters cells and evades the immune system
This study is looking at how a key part of the HIV virus changes shape when it tries to enter human cells, which could help us understand how the virus avoids the immune system and lead to better treatments for people living with HIV.
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Understanding how virus spike proteins help viruses enter cells
This study is looking at how the spike proteins on viruses like SARS-CoV-2 help them get into our cells, which could lead to better vaccines and treatments for everyone.
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Improving treatment for empyema in older patients
This study is looking for better and safer ways to treat empyema in older adults by using new therapies that can help dissolve the fluid without needing surgery, making it easier for those who might have other health problems.
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Training experiences for medical residents in rural and agricultural settings
This study is working to improve the training of doctors who focus on workplace health so they can better help people in rural areas, especially those in farming jobs, by teaching them how to meet the unique health needs of these communities.
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How volcanic ash and certain bacteria affect lung health
This study is looking at how certain cells in your lungs react to volcanic ash and specific bacteria that can cause long-term lung problems, especially in people living in Hawai'i, to help find better ways to prevent and treat these infections.
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Creating a new inhalable treatment for lung scarring diseases
This study is looking at a new inhalable treatment for interstitial lung diseases like idiopathic pulmonary fibrosis, which causes serious lung damage, to see if a special peptide can help protect lung cells and slow down the disease.
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Optimizing cephalosporin treatments for children with multi-drug resistant tuberculosis.
This study is looking at how to use certain antibiotics to help young children, especially those under two, who are fighting tough cases of tuberculosis that don't respond to standard treatments, so they can get better more safely and effectively.
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Investigating how tissue factor contributes to blood clotting issues in COVID-19 patients
This study is looking at how COVID-19 can cause blood clotting problems and aims to find ways to help patients who are experiencing these issues.
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Investigating how Gab2 signaling affects inflammation and blood clotting.
This study is looking at a protein called Gab2 to see how it affects inflammation and blood clotting, which could help us understand conditions like blood clots in the veins, and the findings might lead to better treatments for patients dealing with these issues.
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How a protein affects lung injury caused by silica dust
This study is looking into how silica dust can harm your lungs and how a protein called PAI-1 might be involved in that damage, with the hope of finding better ways to prevent or treat lung diseases like silicosis for people who work in industries like mining and construction.
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