Investigating how specific cell signaling affects blood clot formation
The Role of Gab2-MALT1-mediated cell signaling in venous thrombogenesis
This study is looking into how inflammation causes blood clots in conditions like deep vein thrombosis and pulmonary embolism, with the hope of finding new ways to treat these issues safely and effectively, so patients can have better options with less risk of bleeding.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project ID | NIH-11138576 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind venous thromboembolism (VTE), which includes conditions like deep vein thrombosis and pulmonary embolism. By studying the role of Gab2, a signaling protein in endothelial cells, the research aims to uncover how inflammation contributes to blood clot formation. The goal is to identify new therapeutic targets that could lead to safer and more effective treatments for VTE, reducing the risks associated with current anticoagulant therapies. Patients may benefit from insights that could lead to innovative treatment options that minimize bleeding risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for venous thromboembolism, including those with a history of deep vein thrombosis or pulmonary embolism.
Not a fit: Patients who do not have risk factors for venous thromboembolism or those already effectively managed with current anticoagulant therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for venous thromboembolism.
How similar studies have performed: Other research has shown promise in targeting inflammatory pathways to prevent thromboembolism, suggesting that this approach may yield significant advancements.
Where this research is happening
Tyler, United States
- University of Texas Hlth Ctr at Tyler — Tyler, United States (Active)
Researchers
- Principal investigator: Lella, Vijaya Mohan Rao — University of Texas Hlth Ctr at Tyler
- Study coordinator: Lella, Vijaya Mohan Rao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.