Lipid damage and a form of cell death that turns on blood clotting
Official title: Lipid peroxidation- and pyroptosis-induced tissue factor activation in pathogen-induced blood coagulation
Funded at University of Texas Hlth Ctr at Tyler · NIH-11514482 · Data updated 2026-11-12
This grant explores how certain lipid byproducts and inflammatory cell death trigger tissue factor to start dangerous blood clots, with the aim of finding targets to prevent clot-related heart and vessel problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project start | June 1, 2026 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL166778-03 |
| Project ID | NIH-11514482 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with or at risk for infection-related thrombosis, including those with or at risk for acute myocardial infarction or sepsis.
✕Less likely to help
Individuals without infection-associated coagulopathy or thrombotic risk may not directly benefit.
What this research studies
If this research succeeds, it could reveal how infections can spark abnormal clotting and contribute to heart attacks and strokes. The team will study how lipid peroxidation products like HNE and pyroptosis drive tissue factor activation, focusing on mechanisms involving PS exposure and TMEM16F. Using human-relevant models, the work could point to new ways to block or modulate clotting in infection-related conditions. The findings may inform future therapies to reduce thrombotic risk after acute myocardial infarction or sepsis.
Why it matters
Potential benefit: Potentially leading to new strategies to prevent dangerous blood clots in infection-related conditions.
How similar studies have gone: Prior research has linked lipid peroxidation and pyroptosis to coagulation; this project builds on emerging evidence but remains exploratory.
Where this research is happening
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University of Texas Hlth Ctr at Tyler
Tyler, United States Active
Researchers
- Principal investigator: Ansari, Shabbir Ahmed — University of Texas Hlth Ctr at Tyler
- Study coordinator: Ansari, Shabbir Ahmed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.