Investigating how tissue factor contributes to blood clotting issues in COVID-19 patients
Official title: Tissue Factor's Role in the Pathogenesis of Hypercoagulability in COVID-19
Funded at University of Texas Hlth Ctr at Tyler · NIH-10580840 · Data updated 2026-11-12
This study is looking at how COVID-19 can cause blood clotting problems and aims to find ways to help patients who are experiencing these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2026 |
| Funding year | 2023 |
| Award (this year) | $220,500 |
| NIH project number | 5R21AI163608-02 |
| Project ID | NIH-10580840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include hospitalized COVID-19 patients experiencing severe coagulopathy or thrombotic complications.
✕Less likely to help
Patients who are not infected with SARS-CoV-2 or those without any coagulation disorders may not benefit from this research.
What this research studies
This research explores the role of tissue factor in causing blood clotting problems in patients with COVID-19. It focuses on understanding how the virus affects blood coagulation and leads to serious complications like thrombosis. The study will examine the mechanisms behind increased tissue factor activity and the release of specific extracellular vesicles in the bloodstream. By investigating these processes, the research aims to identify potential treatments that could reduce clotting issues in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates for critically ill COVID-19 patients by addressing blood clotting complications.
How similar studies have gone: Previous research has indicated that targeting coagulation abnormalities in COVID-19 patients can improve outcomes, suggesting that this approach may be promising.
Where this research is happening
-
University of Texas Hlth Ctr at Tyler
Tyler, United States Active
Researchers
- Principal investigator: Lella, Vijaya Mohan Rao — University of Texas Hlth Ctr at Tyler
- Study coordinator: Lella, Vijaya Mohan Rao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.