Understanding why some patients struggle with exercise despite having normal heart function.
Official title: Characterization of Mechanisms of Exercise Intolerance in Patients at Risk for Heart Failure with Preserved Ejection Fraction
Funded at University of Texas Hlth Ctr at Tyler · NIH-11041039 · Data updated 2026-11-12
This study is looking at why some people at risk for heart failure have trouble exercising and doing everyday activities, especially as they get older, and it aims to find ways to help them feel better and move more easily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project start | March 6, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $115,462 |
| NIH project number | 5K24HL166681-03 |
| Project ID | NIH-11041039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults over 21 years old who experience difficulty with exercise or daily activities and are at risk for heart failure with preserved ejection fraction.
✕Less likely to help
Patients who do not have any risk factors for heart failure or those who are unable to participate in exercise testing may not benefit from this research.
What this research studies
This research investigates the mechanisms behind exercise intolerance in patients who are at risk for heart failure with preserved ejection fraction (HFpEF). It aims to identify how age-related changes and other factors affect the ability to perform daily activities and exercise. The study involves comprehensive exercise testing and analysis of biological markers in a diverse group of participants. By understanding these mechanisms, the research seeks to improve exercise tolerance and overall health outcomes for these patients.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for improving exercise capacity and quality of life for patients at risk of heart failure.
How similar studies have gone: Previous research has shown promising results in understanding exercise intolerance in heart failure patients, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Ctr at Tyler
Tyler, United States Active
Researchers
- Principal investigator: Berry, Jarett D — University of Texas Hlth Ctr at Tyler
- Study coordinator: Berry, Jarett D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.