Tiny particles from the clotting protein FVIIa that help stop bleeding and calm inflammation
Factor VIIa-released extracellular vesicles: Their role in hemostasis and beyond
This research looks at whether tiny particles released by the clotting protein FVIIa can help stop bleeding and reduce inflammation for people with bleeding disorders or vascular injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project ID | NIH-11289389 on NIH RePORTER |
What this research studies
The team will examine how FVIIa interacts with blood vessel cells and triggers release of extracellular vesicles (EVs) that carry proteins and signals. They will analyze what these EVs contain and how they change blood clotting and inflammation using lab-grown human endothelial cells and biochemical and imaging tests. The researchers will track how the EVs behave in living systems, using animal models and human-derived samples when available, to see where the EVs go and how long they last. Together these approaches aim to show whether FVIIa-generated EVs could be harnessed or mimicked to protect blood vessels and improve bleeding control.
Who could benefit from this research
Good fit: People with bleeding disorders (for example hemophilia with inhibitors) or patients who receive recombinant FVIIa for severe bleeding could be the most relevant candidates to donate samples or be potential future therapy recipients.
Not a fit: People without bleeding problems or vascular inflammation—or those whose conditions do not involve FVIIa or EPCR pathways—are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this could lead to new treatments that use or mimic these EVs to better control bleeding and protect blood vessels from inflammation.
How similar studies have performed: Prior laboratory studies have shown FVIIa interactions and EVs can influence clotting and inflammation in cells and animals, but translating EV-based approaches into patient treatments is largely untested.
Where this research is happening
Tyler, United States
- University of Texas Hlth Ctr at Tyler — Tyler, United States (Active)
Researchers
- Principal investigator: Lella, Vijaya Mohan Rao — University of Texas Hlth Ctr at Tyler
- Study coordinator: Lella, Vijaya Mohan Rao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.