Investigating the role of Factor VIIa-released extracellular vesicles in blood clotting and inflammation
Official title: Factor VIIa-released extracellular vesicles: Their role in hemostasis and beyond
Funded at University of Texas Hlth Ctr at Tyler · NIH-11052656 · Data updated 2026-11-12
This study is looking at how a protein called Factor VIIa works with other proteins to help control bleeding and inflammation, and it hopes to find new ways to treat bleeding disorders by exploring tiny particles released from blood vessel cells that carry important signals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project start | March 15, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $610,927 |
| NIH project number | 5R01HL169255-02 |
| Project ID | NIH-11052656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with bleeding disorders, such as hemophilia, or those experiencing severe bleeding due to surgery or other medical conditions.
✕Less likely to help
Patients with non-bleeding related conditions or those who do not have any coagulation disorders may not receive benefits from this research.
What this research studies
This research focuses on understanding how Factor VIIa, a key protein in blood clotting, interacts with other proteins to influence bleeding and inflammation. It explores the release of extracellular vesicles from endothelial cells, which are small particles that can carry important signals in the body. By studying these vesicles, the research aims to uncover their potential therapeutic benefits in treating bleeding disorders and other related conditions. Patients may benefit from insights into new treatments that could improve blood coagulation and reduce inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance blood clotting and reduce inflammation in patients with bleeding disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of extracellular vesicles in various medical conditions, indicating that this approach may yield valuable insights.
Where this research is happening
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University of Texas Hlth Ctr at Tyler
Tyler, United States Active
Researchers
- Principal investigator: Lella, Vijaya Mohan Rao — University of Texas Hlth Ctr at Tyler
- Study coordinator: Lella, Vijaya Mohan Rao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.