Sponsor or institution
Clinical trials and research at Research Inst Nationwide Children's Hosp
As of November 12, 2026, Find a Trial lists 290 NIH-funded research projects at this institution, with $177.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 290NIH research projects
NIH-funded research (newest 40 of 290)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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A center focused on immunotherapy for pediatric cancers.
This study is exploring new ways to use the body's immune system to fight childhood cancers, aiming to create better treatments for kids whose cancers haven't responded well to standard therapies.
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Atomoxetine for MC4R obesity in children
A trial tests whether an ADHD drug, atomoxetine, can help children with a genetic form of obesity caused by MC4R mutations.
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Collaborative Pediatric Critical Care Network: Clinical Site
A nationwide network study aims to tailor sepsis treatment for children with organ failure based on each child’s immune profile.
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How dietary fats may make platelets overactive in obesity
A study in adults with obesity will explore how saturated fats in the diet change platelet membranes and make platelets act more likely to clump and react, which could affect heart and blood vessel health.
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Understanding how environment and microbiome affect health in children with sickle cell disease
A research project will explore how environmental exposures shape immune responses and airway microbiomes in children with sickle cell disease and how these factors relate to health outcomes.
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Pediatric cancer biospecimen bank and research collaboration fund
This grant supports the Children’s Oncology Group to collect, bank, and share tumor and other biospecimens from children and adolescents with cancer for research.
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SWOG Biospecimen Bank Support for Cancer Trials
A national cancer research group is expanding its tumor/biospecimen bank to support adult cancer trials and improve access to high-quality samples for researchers.
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EET Biobank: A National Cancer Biorepository for Early-Phase Trials
A national biobank is expanding to collect and share high-quality cancer biospecimens and clinical data from patients in early-phase and experimental cancer trials to speed new treatments.
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Understanding infantile rhabdomyosarcoma biology and new treatment targets
A new grant is studying why infantile rhabdomyosarcoma develops and what drugs or strategies could specifically target it in young children.
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Teen Period app study to understand menstruation and iron deficiency in newly tapped teens
A national study using a teen-friendly mobile app to track menstruation and identify factors linked to iron deficiency in girls who have just started menstruating.
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Effect of electronic cigarette vapor on ear infections and bacterial communities in kids
A study tests how exposure to e-cigarette vapor may affect kids’ risk of ear infections and the behavior of bacteria that cause them.
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Understanding how MPZ mutations cause CMT1B and exploring gene therapy approaches
A patient-focused research project aims to understand why MPZ gene changes cause Charcot-Marie-Tooth type 1B and to test a potential gene therapy strategy.
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Heart development study using patient stem cells to understand NOTCH1 and congenital heart disease
A study using patient-derived stem cells and genome editing to learn how NOTCH1 affects early heart development and congenital heart defects in humans.
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Understanding how human antimicrobial peptides RNase3, RNase6, and RI help prevent and treat urinary tract infections
A research project is exploring how natural antibacterial proteins in the urinary tract could protect against UTIs and reduce kidney damage, with the goal of developing new treatments.
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Targeting purine metabolism to modulate T cell autoimmune activity
Aims to understand how purine nutrients and signaling control T-cell inflammation in autoimmune diseases to identify new therapeutic strategies.
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New ways to stop osteosarcoma from spreading
Researchers are testing new approaches to block how osteosarcoma spreads, with the aim of improving survival for children and adults with metastatic disease.
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Second-generation tissue-engineered vascular grafts for infants and children with congenital heart disease
A study to test a biosynthetic graft grown from a patient’s own cells to help babies and kids with heart defects, aiming for safer, growing blood vessels that work with their bodies.
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AI for Dating Healing Fractures in Young Children
A new AI tool uses pediatric imaging to more accurately determine how long a healing fracture has been present in children, helping doctors evaluate possible abuse.
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Smartphone virtual reality to ease pain for kids during burn care at home
A smartphone-based virtual reality tool called VR-PAT is being tested to help children feel less pain and use fewer opioid medicines when they shift from hospital care to home burn dressing changes.
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Safer Still: helping families keep firearms safely after a teen’s hospital stay
A project to help parents of high-risk teens store firearms safely after being discharged from psychiatric care, using easy nudges delivered through technology.
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Support for suicide-prevention care in pediatric primary care
A nationwide program is testing a way to help doctors in primary care prevent suicide attempts among youth, using a stepped approach to put proven practices into routine care.
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ASPIRES Methods Core for youth suicide prevention
A NIH grant supports a team effort to design, test, and spread better, real-world strategies to reduce youth suicide.
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Administrative Core for ASPIRES: Coordinating Youth Suicide Prevention Efforts
This grant funds the Administrative Core of a center aiming to speed up delivery of youth suicide prevention tools and services in clinical and community settings to reduce youth suicides.
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Center to speed up real-world youth suicide prevention
A nationwide effort to put proven youth suicide prevention strategies into everyday health care so that at-risk kids get help faster.
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Understanding infantile rhabdomyosarcoma biology and new treatment targets
A study to learn why a rare cancer in very young children grows and to find ways to stop it with targeted therapies.
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Molecular imaging of artery disease in leg arteries
A new imaging approach uses a special PET/CT scan to map blood flow and mineral buildup in leg arteries of people with PAD.
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Midwest Pediatric Device Consortium helps get child-friendly medical devices to market
A regional program provides funding and expert support to inventors creating pediatric medical devices to address unmet health needs in kids.
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Pathophysiology-based GERD management in NICU infants guided by pH-impedance testing
A NICU randomized trial tests how newborns with suspected GERD respond to standard care, acid-suppressing therapy, or thicker feeds guided by objective pH-impedance tests.
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Targeting Mitochondrial Superoxide to Repair Cisplatin Kidney Injury
This project tests a treatment that could protect the kidneys of patients receiving cisplatin chemotherapy by boosting mitochondrial antioxidant defense in kidney tubule cells.
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Make Play Safe: A youth soccer program to help kids recognize and report concussions
A program uses virtual reality and coaching strategies to help kids, parents, and coaches recognize and report concussions in youth soccer.
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Extracellular Vesicles to Monitor and Improve Dystrophinopathy
A patient-friendly grant focusing on Duchenne muscular dystrophy uses tiny particles in the blood to track disease and help guide future therapies.
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Personalized RNA Vector Therapy for Dystrophinopathy (Becker/DMD)
A patient-friendly look at a project that aims to customize a genetic therapy to help people with Duchenne/Becker muscular dystrophy using AAV-delivered RNA to restore dystrophin.
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Bicistronic gene therapy for limb girdle muscular dystrophy type R9
A patient-facing overview of a first-in-class gene therapy approach using two genes delivered by AAV to help people with LGMDR9.
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Muscular Dystrophy Cell Line and Serum Banking Core
A dedicated resource that creates and stores patient-derived muscle-related cell lines and blood samples to speed the development of genetic therapies for muscular dystrophy.
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Muscle Disease Training Program for Clinicians and Scientists at Nationwide Children’s Hospital and OSU
A comprehensive training program in Columbus, Ohio is helping clinicians and scientists learn and advance muscle disease therapies and gene therapy approaches.
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MDSRC Administrative Core supports muscular dystrophy therapies
This grant supports a center that accelerates therapies for muscular dystrophy, including Duchenne and LGMD2I, by sharing expertise and coordinating projects across teams.
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MDSRC for Next Directions in Muscular Dystrophy Research
A major research center grant aims to speed new gene therapy ideas for muscular dystrophy by sharing expertise, creating tools, and advancing three focused projects.
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PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients
A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.
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Glutathione reductase and neutrophil battles bacteria and fungi
This grant studies how neutrophils use a chemical called glutathione to fight infections, which could help improve immune responses in people with bacterial or fungal infections.
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Clinical Trial Readiness for Very Young Children with LAMA2-Related Muscular Dystrophy
Aims to prepare very young children with LAMA2-related muscular dystrophy for future therapies by validating measurements and biomarkers that can track progress.
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