Glutathione reductase and neutrophil battles bacteria and fungi
Official title: Glutathione reductase (Gsr) regulates cell metabolism and signaling during neutrophil-pathogen interactions
Funded at Research Inst Nationwide Children's Hosp · NIH-11395628 · Data updated 2026-11-12
This grant studies how neutrophils use a chemical called glutathione to fight infections, which could help improve immune responses in people with bacterial or fungal infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | August 18, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $527,960 |
| NIH project number | 5R01AI193143-02 |
| Project ID | NIH-11395628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with recurrent or difficult-to-treat bacterial or fungal infections or those with blood-related neutrophil concerns who could contribute or benefit from translational studies related to neutrophil metabolism.
✕Less likely to help
Patients without neutrophil-related immune issues or those not eligible for participation in related translational efforts may see no direct benefit.
What this research studies
Researchers will look at how glutathione reductase affects how neutrophils use metabolism and signaling to kill invading bacteria and fungi. By studying neutrophil metabolism and reactive oxygen species production in mouse models and human cells, they aim to link enzyme activity to immune effectiveness. The work could reveal new angles to boost infection-fighting neutrophil function in patients who struggle to clear infections.
Why it matters
Potential benefit: Finding ways to strengthen neutrophil defense could lead to better therapies for bacterial and fungal infections.
How similar studies have gone: Previous mouse studies show that glutathione reductase influences neutrophil function and infection control, supporting potential translational relevance.
Where this research is happening
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Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Liu, Yusen — Research Inst Nationwide Children's Hosp
- Study coordinator: Liu, Yusen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.