Second-generation tissue-engineered vascular grafts for infants and children with congenital heart disease
Official title: A Study Evaluating the Safety and Efficacy of Second-Generation Tissue Engineered Vascular Grafts (TEVG2)
Funded at Research Inst Nationwide Children's Hosp · NIH-11444096 · Data updated 2026-11-12
A study to test a biosynthetic graft grown from a patient’s own cells to help babies and kids with heart defects, aiming for safer, growing blood vessels that work with their bodies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $974,238 |
| NIH project number | 2UH3HL148693-06 |
| Project ID | NIH-11444096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants and children with congenital heart disease who may need vascular grafts as part of their treatment.
✕Less likely to help
Children not requiring a vascular graft or those with conditions not addressed by this graft approach.
What this research studies
This project builds grafts from autologous tissue to repair or replace diseased blood vessels in young patients with congenital heart disease. Researchers will monitor how well the grafts work over time, looking at safety, function, and growth in the developing cardiovascular system. The work follows previous clinical experiences with a tissue-engineered graft and seeks to confirm its advantages over conventional prosthetic materials. Families participating would follow postoperative care plans and undergo regular check-ups to track graft performance. The study emphasizes biocompatibility, reduced complications, and the potential for the graft to grow with the child.
Why it matters
Potential benefit: If successful, children may have safer grafts that grow with them and reduce complications compared with standard prosthetic materials.
How similar studies have gone: Previous clinical work suggested the TEVG could outperform standard grafts in terms of growth, biocompatibility, and fewer adverse events.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Breuer, Christopher Kane — Research Inst Nationwide Children's Hosp
- Study coordinator: Breuer, Christopher Kane
Related research
Other NIH-funded projects on the same topics.
-
A center focused on immunotherapy for pediatric cancers.
This study is exploring new ways to use the body's immune system to fight childhood cancers, aiming to create better treatments for kids whose cancers haven't responded well to standard therapies.
-
Atomoxetine for MC4R obesity in children
A trial tests whether an ADHD drug, atomoxetine, can help children with a genetic form of obesity caused by MC4R mutations.
-
Collaborative Pediatric Critical Care Network: Clinical Site
A nationwide network study aims to tailor sepsis treatment for children with organ failure based on each child’s immune profile.
-
How dietary fats may make platelets overactive in obesity
A study in adults with obesity will explore how saturated fats in the diet change platelet membranes and make platelets act more likely to clump and react, which could affect heart and blood vessel health.
-
Understanding how environment and microbiome affect health in children with sickle cell disease
A research project will explore how environmental exposures shape immune responses and airway microbiomes in children with sickle cell disease and how these factors relate to health outcomes.
-
Pediatric cancer biospecimen bank and research collaboration fund
This grant supports the Children’s Oncology Group to collect, bank, and share tumor and other biospecimens from children and adolescents with cancer for research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.