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Clinical trials and research at Ottawa Hospital Research Institute

• 51Clinical trials
• 1NIH research projects
• 1New in 30 days
• 7Countries

Newest trials

All recruiting trials (51)

• One-time Pain Reprocessing Therapy session for chronic pain at The Ottawa Hospital

  A single four-hour session of Pain Reprocessing Therapy is being tested to see if it can help adults with chronic pain feel better and have less pain.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07919626

• Blood Transfusion Thresholds During Major Surgery

  This study tests whether a higher versus lower blood transfusion threshold during surgery helps reduce serious complications or death after major surgery.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT07748663

• Brain scans to find links between brain activity and knee replacement outcomes

  This study uses brain MRI before and after knee replacement to see if patterns of brain activity can predict which patients will be satisfied with their surgery.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07464080

• Safety of perioperative blood thinner management in people with cancer undergoing surgery or procedures

  This study tests how safe current practices are for stopping or continuing blood thinners in adults with cancer who are having surgery or procedures, to see if bleeding or clots are affected.

  Recruiting Ottawa Hospital Research Institute · Ottawa · NCT07372716

• Morning versus evening timing of hormone therapy for metastatic breast and prostate cancer

  This pilot will test whether taking hormone-based cancer drugs in the morning or in the evening works better for people with metastatic breast or prostate cancer.

  Recruiting at 2 sites Phase 4 Ottawa Hospital Research Institute · Kitchener, Ontario and 2 other locations · NCT07252726

• Fractional CO2 laser for chronic Peyronie's disease

  This will try fractional CO2 laser to reduce plaque-related penile curvature and symptoms in men with chronic, stable Peyronie's disease.

  Recruiting Phase 1 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07177833

• Daily vacuum device therapy for penile numbness and sensation changes

  This will try daily use of a Health Canada–approved vacuum erection device for six months in adult men with penile numbness to see if people can use it regularly and whether symptoms change.

  Recruiting Early Phase 1 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07171567

• Personalized outpatient hypoglycemia treatment

  This test tries whether adults with type 2 diabetes can safely treat mild low blood sugar by choosing how much quick carbohydrate to take and when to recheck their fingerstick.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07094529

• Pre-surgery heart and breathing variability to spot risk of complications after major thoracic cancer surgery.

  This project will test whether a quick pre-surgery check of heart and breathing variability can help predict which adults having major thoracic cancer operations are more likely to have postoperative complications.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07016022

• Low-dose steroid treatment with standard induction medicines for ANCA-associated vasculitis affecting the kidneys

  This trial will test whether giving only 4 weeks of steroids together with usual induction medicines (cyclophosphamide or rituximab) helps people with ANCA-associated vasculitis that has severely affected the kidneys while reducing steroid-related harms.

  Recruiting Phase 3 Ottawa Hospital Research Institute · Hamilton, Ontario and 1 other locations · NCT06983821

• Full-dose versus low-dose rivaroxaban for superficial vein clots in the leg

  This pilot will try full-dose rivaroxaban against the usual low dose (followed by placebo) in adults with superficial vein clots in the leg to see if the plan can recruit and run well.

  Recruiting Phase 2/3 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT06965998

• Developing a risk score for blood clots in cancer patients

  This study is trying to create a tool to help doctors figure out which cancer patients are at higher or lower risk for blood clots and bleeding after their diagnosis.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06894576

• Timing of Temozolomide for Glioblastoma Treatment

  This study is testing whether taking the cancer drug temozolomide in the morning or evening helps people with glioblastoma feel better and have fewer side effects.

  Recruiting at 2 sites Ottawa Hospital Research Institute · London, Ontario and 1 other locations · NCT06850766

• Comparing induction of labor versus expectant management for gestational diabetes

  This study is testing if inducing labor at 38 weeks for people with gestational diabetes can lower the chances of serious complications for their babies compared to waiting for labor to start on its own.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06641141

• Managing blood clot prevention in cancer patients with catheter-related DVT

  This study is testing whether giving a low dose of a blood thinner to cancer patients with a history of blood clots can help prevent new clots from forming.

  Recruiting at 2 sites Phase 4 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT06603870

• Prehabilitation program before surgery to reduce complications

  This study is testing if a home-based program to help people get stronger before surgery can reduce complications and improve recovery for patients facing surgery.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06511258

• Virtual care to help older surgical patients with frailty recover at home

  This study tests if using virtual care with CloudDX technology can help older patients with frailty recover better at home after surgery compared to regular care.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06503198

• Testing insulin production in people with type 2 diabetes

  This study tests how well the pancreas makes insulin in people with type 2 diabetes after they drink a meal replacement shake.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06462170

• Colchicine to reduce inflammation after proximal deep vein thrombosis

  This trial will try daily low‑dose colchicine (0.5 mg) versus a matching placebo in adults with a first proximal lower‑leg DVT to see if it lowers the chance of developing post‑thrombotic syndrome.

  Recruiting at 3 sites Phase 3 Ottawa Hospital Research Institute · Ottawa, Ontario and 3 other locations · NCT06440694

• Lowering stomach and intestinal bleeding with omeprazole in older adults with a new blood clot

  This pilot will test whether taking omeprazole reduces stomach or intestinal bleeding in people 65 and older who are starting blood thinners for a new venous blood clot.

  Recruiting at 6 sites Phase 3 Ottawa Hospital Research Institute · Ottawa, Ontario and 6 other locations · NCT06393868

• Identifying and treating undiagnosed asthma or COPD in Canadians

  This study is trying to find Canadians who might have asthma or COPD without knowing it and see if getting diagnosed and treated early can improve their quality of life.

  Recruiting at 6 sites Ottawa Hospital Research Institute · Hamilton, Ontario and 5 other locations · NCT06392776

• Evaluating anesthesia types for lower limb surgery

  This study is trying to see if using different types of anesthesia during lower limb surgery can improve recovery for adults who are scheduled for these procedures.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06067789

• Using umbilical mesenchymal stromal cells to treat septic shock

  This study is testing whether giving umbilical stem cells can help people with septic shock recover better than a placebo.

  Recruiting at 2 sites Phase 2 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT05969275

• Preventing blood clots in cancer patients receiving treatment

  This study is testing if the blood thinner rivaroxaban can help prevent blood clots in cancer patients with genitourinary cancers who are starting treatment.

  Recruiting Phase 2/3 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05920343

• Focal dose escalation for localized prostate cancer treatment

  This study is testing a new way to treat localized prostate cancer by giving higher doses of radiation in a shorter time while also using hormone therapy to see if it works better and causes fewer side effects.

  Recruiting Phase 2 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05851547

• Cold versus room-temperature platelet storage for treating bleeding in hematologic malignancy

  This pilot will test whether cold-stored platelets stop bleeding better than room-temperature platelets in adults with hematologic cancers or marrow aplasia who need a platelet transfusion.

  Recruiting Phase 2 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05820126

• Evaluating the need for G-CSF in breast cancer patients on chemotherapy

  This study is testing if breast cancer patients on a specific chemotherapy can skip a medication called G-CSF to see if it helps reduce side effects without affecting their treatment success.

  Recruiting at 3 sites Phase 4 Ottawa Hospital Research Institute · Kingston, Ontario and 2 other locations · NCT05753618

• Screening for hidden cancers in patients with unexplained strokes

  This study is testing if adding special scans to regular cancer checks can help find hidden cancers in people who have had unexplained strokes.

  Recruiting at 2 sites Ottawa Hospital Research Institute · Calgary, Alberta and 2 other locations · NCT05733416

• Evaluating a new surgical irrigation method for joint replacement surgeries

  This study is testing a new way to clean the surgical area during knee or hip replacement surgeries to see if it can lower the risk of infections compared to the usual method.

  Recruiting at 8 sites Ottawa Hospital Research Institute · Vancouver, British Columbia and 7 other locations · NCT05543941

• Improving extubation decisions for critically ill patients

  This study is testing a new tool to help doctors decide when critically ill patients are ready to be taken off breathing machines, aiming to improve their recovery and reduce risks.

  Recruiting at 12 sites Ottawa Hospital Research Institute · Edmonton, Alberta and 11 other locations · NCT05506904

• Comparing two shoulder surgeries for older patients with osteoarthritis

  This study is testing which shoulder surgery works better for older patients with severe arthritis: a total shoulder replacement or a reverse shoulder replacement.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05487274

• Modafinil to reduce fatigue and thinking problems in advanced cancer

  This project tests whether modafinil helps people with advanced cancer who have significant fatigue and related thinking problems.

  Recruiting Phase 1/2 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05333250

• Examining gut microbiome effects in glioblastoma patients undergoing treatment

  This study is trying to see if changes in gut bacteria can affect how well treatment works for adults with newly diagnosed glioblastoma who are getting chemotherapy and radiation.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05326334

• Assessing anticoagulation safety after gastrointestinal bleeding

  This study is testing a new way to safely restart blood thinners for patients who have had serious stomach bleeding to see how soon it can be done without causing more problems.

  Recruiting at 2 sites Ottawa Hospital Research Institute · Calgary, Alberta and 1 other locations · NCT05290857

• Strategies for anticoagulation in cancer patients with low platelet counts and blood clots

  This study is testing two different ways to treat blood clots in cancer patients with low platelet counts to see which method causes fewer bleeding problems.

  Recruiting at 3 sites Phase 4 Ottawa Hospital Research Institute · Edmonton, Alberta and 3 other locations · NCT05255003

• Hormonal therapy's effect on prostate cancer recurrence after surgery

  This study tests if giving hormone therapy right after prostate surgery can help prevent cancer from coming back in men at high risk of recurrence.

  Recruiting at 2 sites Phase 3 Ottawa Hospital Research Institute · Halifax, Nova Scotia and 2 other locations · NCT05169112

• Remote cardiac monitoring for patients at risk of fainting after emergency department discharge

  This study is testing if a special heart monitor can help find serious heart problems in adults who faint and are at risk after leaving the emergency room.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05066347

• Preventing blood clots in cancer patients with central venous catheters

  This study is testing if a daily dose of a blood thinner called rivaroxaban can help prevent blood clots in cancer patients who have just had a central venous catheter placed.

  Recruiting at 11 sites Phase 3 Ottawa Hospital Research Institute · Halifax, Nova Scotia and 10 other locations · NCT05029063

• Implementing a risk score for patients with syncope in emergency departments

  This study is testing a new scoring system in emergency departments to help doctors make better decisions for patients who faint, aiming to reduce unnecessary hospital stays.

  Recruiting at 15 sites Ottawa Hospital Research Institute · Calgary, Alberta and 14 other locations · NCT04972071

• See if older patients with low-risk HR+ breast cancer can skip endocrine therapy

  This trial tests whether people aged 70 and older with low‑risk, hormone receptor–positive breast cancer can omit endocrine therapy after surgery and radiotherapy.

  Recruiting Phase 4 Ottawa Hospital Research Institute · Edmonton, Alberta and 7 other locations · NCT04921137

• Evaluating integrative care for patients undergoing surgery for thoracic cancers

  This study is testing whether adding natural health products like Vitamin D3, probiotics, and whey protein can help improve recovery and quality of life for patients having surgery for lung, gastric, and esophageal cancers.

  Recruiting at 2 sites Phase 3 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT04871412

• Using albumin to improve recovery in critically ill patients with acute kidney injury

  This study is testing whether giving critically ill patients with acute kidney injury a special type of albumin instead of regular saline can help them recover better and need less kidney treatment.

  Recruiting at 9 sites Phase 4 Ottawa Hospital Research Institute · Calgary, Alberta and 15 other locations · NCT04705896

• Comparing bleeding risks of two blood thinners in patients with atrial fibrillation

  This study is testing which of two blood thinners, apixaban or rivaroxaban, is safer for people with atrial fibrillation by looking at their bleeding risks over a year.

  Recruiting at 6 sites Phase 4 Ottawa Hospital Research Institute · Victoria, British Columbia and 7 other locations · NCT04642430

• Using Tranexamic Acid to Reduce Platelet Transfusions in Stem Cell Transplant Patients

  This study is testing if giving Tranexamic Acid along with platelet transfusions can help stem cell transplant patients need fewer transfusions and stay safer during their treatment.

  Recruiting at 8 sites Phase 3 Ottawa Hospital Research Institute · Calgary, Alberta and 11 other locations · NCT04448184

• Using rosuvastatin to reduce blood clots in patients with venous thromboembolism

  This study is testing if adding rosuvastatin, a cholesterol-lowering drug, can help prevent blood clots from coming back in patients who have recently had a major blood clot event.

  Recruiting at 19 sites Phase 3 Ottawa Hospital Research Institute · Calgary, Alberta and 30 other locations · NCT04319627

• Comparing total and reverse shoulder arthroplasty for shoulder osteoarthritis in older adults

  This study is testing whether total shoulder surgery or reverse shoulder surgery works better for older adults with shoulder arthritis who haven't found relief from other treatments.

  Recruiting at 2 sites Ottawa Hospital Research Institute · Edmonton, Alberta and 3 other locations · NCT04228419

• CLIC-1901 treatment for relapsed/refractory CD19 positive blood cancers

  This study is testing a new treatment called CLIC-1901 for people with hard-to-treat blood cancers to see if it can help them feel better.

  Recruiting at 2 sites Phase 1/2 Ottawa Hospital Research Institute · Vancouver, British Columbia and 2 other locations · NCT03765177

• Comparing hip surgery techniques for hip dysplasia

  This study is testing if adding a hip surgery to fix joint issues improves recovery for people with hip dysplasia compared to just the main surgery alone.

  Recruiting at 7 sites Ottawa Hospital Research Institute · Chicago, Illinois and 6 other locations · NCT03481010

• Comparing vacuum dressings to standard dressings after surgery for soft tissue sarcoma

  This study is testing if using vacuum dressings instead of standard dressings after surgery can help patients with soft tissue sarcoma heal better and improve their quality of life.

  Recruiting at 2 sites Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT03175718

• In-clinic removal of nasal polyps for chronic sinusitis

  This study tests if a new in-clinic procedure for removing nasal polyps can help people with chronic sinusitis just as much as the traditional surgery done in an operating room, while being quicker and cheaper.

  Recruiting at 4 sites Ottawa Hospital Research Institute · Vancouver, British Columbia and 3 other locations · NCT02975310

• Surgical techniques for shoulder osteoarthritis treatment

  This study is testing different surgical methods for treating shoulder osteoarthritis to see which one helps patients feel better and improves their quality of life after surgery.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT02966886

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Genes that help muscles heal

  This project looks at a special group of muscle stem cells and the genes they use to learn how muscles repair themselves, which could help people with muscle injuries or age-related muscle weakness.

  NIH research Ottawa Hospital Research Institute · Ottawa, Canada · NIH-11193224

Quick answers

How many clinical trials run by Ottawa Hospital Research Institute are recruiting right now?

51, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in Canada (51 trials), France (1 trial), Ireland (1 trial), Italy (1 trial), Norway (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 8, Phase 4: 7, Phase 2: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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