Comparing hip surgery techniques for hip dysplasia

Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology: A Multicenter Randomized Controlled Trial

This study is testing if adding a hip surgery to fix joint issues improves recovery for people with hip dysplasia compared to just the main surgery alone.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 204 (estimated)
• Ages: 16 Years to 50 Years
• Sex: All
• Sponsor: Ottawa Hospital Research Institute (Academic / other)
• Locations: 7 sites (Chicago, Illinois and 6 other locations)
• Trial ID: NCT03481010 on ClinicalTrials.gov

What this trial studies

This research project investigates whether performing a hip arthroscopy alongside a periacetabular osteotomy (PAO) improves patient outcomes for individuals with hip dysplasia. Patients will be randomized to receive either a PAO alone or a PAO combined with hip arthroscopy, which allows for the treatment of additional joint abnormalities. The study aims to assess symptomatic differences between the two groups over a follow-up period of two years. By analyzing the effectiveness of these surgical approaches, the study seeks to provide insights into optimal treatment strategies for hip dysplasia.

Who should consider this trial

Good fit: Ideal candidates are skeletally mature individuals aged 16-50 undergoing PAO for symptomatic acetabular dysplasia or hip instability.

Not a fit: Patients with prior hip surgeries, significant arthritis, or certain connective tissue disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and quality of life for patients with hip dysplasia.

How similar studies have performed: While the combination of PAO and hip arthroscopy is a common consideration, this specific comparison is novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

* Skeletally mature patient undergoing Bernese periacetabular osteotomy for symptomatic acetabular dysplasia/hip instability
* Pre-Operative MRI at 3T and/or gadolinium MR arthrogram
* Age, 16-50 years old
* Patient capable of giving informed consent

Exclusion Criteria:

* Prior hip/pelvis surgery of any kind on the surgical side
* Prior hip arthroplasty surgery on either side
* Radiographic evidence of arthritis (i.e. Tönnis grade =2)
* Known connective tissue disorder (e.g. Ehlers-Danlos Syndrome, etc.)
* Known neuromuscular disorder (e.g. Cerebral Palsy, Spina bifida, etc.)
* Known skeletal dysplasia (e.g. Achondroplasia, Multiple Epiphyseal Dysplasia, etc.)
* Cognitive impairment that prevents accurate completion of patient-reported outcome questionnaires.
* Patient unable/unwilling to complete all required follow-up visits
* Concurrent proximal femoral osteotomy and/or surgical hip dislocation

Where this trial is running

Chicago, Illinois and 6 other locations

• Northwestern University — Chicago, Illinois, United States (Recruiting)
• William Beaumont Hospital — Royal Oak, Michigan, United States (Recruiting)
• The Washington University — St Louis, Missouri, United States (Recruiting)
• Hospital for Special Surgery — New York, New York, United States (Recruiting)
• Children's Hospital of Eastern Ontario — Ottawa, Ontario, Canada (Recruiting)
• Ottawa Hospital Research Institute — Ottawa, Ontario, Canada (Recruiting)
• CHU de Québec - Université Laval — Québec, Canada (Recruiting)

Study contacts

• Principal investigator: Geoffrey Wilkin, MD — Ottawa Hospital Research Institute
• Study coordinator: Geoffrey Wilkin, MD

Conditions Hip Dysplasia