Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Testing insulin production in people with type 2 diabetes

Official title: The Feasibility of an Innovative Protocol to Demonstrate the Impact of Positive Energy Balance on Pancreatic Insulin Production Capacity (PIPC)

Run by Ottawa Hospital Research Institute · NCT06462170 · Data updated 2026-11-12

This study tests how well the pancreas makes insulin in people with type 2 diabetes after they drink a meal replacement shake.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment90 (estimated)
SponsorOttawa Hospital Research Institute
Academic / other
Locations1 site (Ottawa, Ontario)
StatusRecruiting
StartedJune 24, 2024
Main results expectedJune 30, 2026
Study endsDecember 31, 2026
Registry record updatedMay 6, 2026
Trial IDNCT06462170 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older diagnosed with type 2 diabetes who are not on insulin therapy.

Probably not a fit

Patients with other forms of diabetes or those allergic to ingredients in the meal replacement shake may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the ability of the pancreas to produce insulin in individuals with type 2 diabetes. Participants will consume a standardized meal replacement shake, and their blood will be tested for insulin and glucose levels over a two-hour period. The study aims to measure differences in insulin production among participants and understand the underlying reasons for these differences. A total of 90 participants will be involved in this cross-sectional study, which involves a single visit for blood sampling at five time points.

Why it matters

Potential benefit: If successful, this study could lead to better understanding and management of insulin production in patients with type 2 diabetes.

How similar studies have gone: While this approach is focused on insulin production capacity, similar studies have shown promise in understanding diabetes management, making this a potentially valuable investigation.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Consent provided
2. Age \>= 18 years.
3. Diagnosed as type 2 diabetes mellitus.
4. Not on insulin therapy.

Exclusion Criteria:

1. Diagnosed as another form of diabetes mellitus.
2. Allergic to one or more ingredients in Boost meal replacement shake.
3. Unable to fast since midnight and attend in person for the morning protocol.

Where it's running

  • The Ottawa Hospital
    Ottawa, Ontario, Canada
    Recruiting

Study contacts

  • Principal investigator: Cathy Sun, MD MSc — Ottawa Hospital Research Institute
  • Study coordinator: Cathy Sun, MD MSc
  • Email: csun@toh.ca
  • Phone: 613-738-8333

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.