Pre-surgery heart and breathing variability to spot risk of complications after major thoracic cancer surgery.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will perform a preoperative CardioPulmonary Variability Assessment—measuring heart rate and respiratory variability—on adults scheduled for major thoracic resections for lung, esophageal, gastric cancer, or mediastinal tumors. Researchers will follow patients through surgery and the postoperative period to record adverse events, length of stay, and other outcomes. The aims are to test feasibility of the preoperative measure, determine whether reduced cardio-pulmonary variability is associated with postoperative adverse events, and explore whether the measure improves risk prediction beyond current clinical factors. Key exclusions include urgent/emergent cases, pre-existing atrial arrhythmias or pacemaker dependence, pregnancy, and inability to complete the preoperative testing protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient (≥18 years of age)
* Patients undergoing major thoracic resection for lung, esophageal or gastric cancer or mediastinal tumour (at least lobectomy, pneumonectomy, esophagectomy, gastrectomy, or mediastinal tumour resection)

Exclusion Criteria:

* Urgent/emergent cases
* Patients with pre-existing atrial fibrillation or arrhythmia (persistent/paroxysmal)
* Patients that are pacemaker dependent
* Patients unable to participate in preoperative testing protocol (CardioPulmonary Variability Assessment)
* Patients that are pregnant

Where it's running

• The Ottawa Hospital
  Ottawa, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Andrew JE Seely, MD, PhD, FRSCS — The Ottawa Hospital
• Study coordinator: Andrew JE Seely, MD,PhD,FRSCS
• Email: aseely@toh.ca
• Phone: 713-737-8899

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.