Identifying and treating undiagnosed asthma or COPD in Canadians

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to identify Canadians who may have undiagnosed asthma or chronic obstructive pulmonary disease (COPD) using an online questionnaire developed by the research team. Individuals who score a certain probability of having these conditions will be invited to participate in a randomized controlled trial to assess the impact of early diagnosis and treatment on their quality of life. The study focuses on symptomatic individuals aged 18 and older who can perform lung function tests. The goal is to improve health outcomes for those with previously undiagnosed respiratory conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals at least 18 years old
* Individuals must be symptomatic with respiratory symptoms
* Individuals must complete the UCAP-Q questionnaire and score a ≥ 6% probability of having either asthma or COPD.
* Individuals who have given written informed consent to participate in this trial in accordance with local regulations;
* Individual must be able to perform pre and post bronchodilator spirometry to measure lung function

Additional Inclusion Criteria for the Randomized Controlled Trial (RCT):

* Individuals who have undiagnosed airflow obstruction on spirometry testing (i.e. Asthma or COPD) will be asked to participate in the RCT.

Exclusion Criteria:

* Individuals who report a previous diagnosis of asthma, COPD, history of lung cancer, bronchiectasis, interstitial lung disease, cystic fibrosis or other significant diagnosed lung disease.
* Individuals currently under the care of a Respirologist.
* Individuals currently using inhaled corticosteroids or long-acting bronchodilators.
* Individuals with history of myocardial infarction, stroke, aortic or cerebral aneurysm, or detached retina or eye surgery within the past 3 months (spirometry is contraindicated)
* Individuals who are in the third trimester of pregnancy
* Individuals involved in another interventional trial

Where it's running

• St. Joseph's Hamilton Healthcare
  Hamilton, Ontario, Canada Recruiting
• Kingston Health Sciences Centre/Queen's University
  Kingston, Ontario, Canada Recruiting
• Ottawa Hospital General Campus
  Ottawa, Ontario, Canada Recruiting
• St. Michael's Hospital/Unity Health Toronto
  Toronto, Ontario, Canada Recruiting
• Institut universitaire de cardiologie et de pneumologie de Québec
  Québec, Quebec, Canada Recruiting
• Royal University Hospital
  Saskatoon, Saskatchewan, Canada Recruiting

Study contacts

• Principal investigator: Shawn Aaron, MD — Ottawa Hospital Research Institute
• Study coordinator: Shawn Aaron, MD
• Email: saaron@toh.ca
• Phone: 6137378259

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.