Sponsor or institution
Clinical trials and research at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
As of November 12, 2026, Find a Trial lists 181 NIH-funded research projects at this institution, with $113.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 181NIH research projects
NIH-funded research (newest 40 of 181)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding Invisible Suicide Risks in Youth: A National Study in Guyana
A nationwide study in Guyana aims to learn about hidden factors that contribute to suicide risk among young people so we can prevent tragedy.
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Understanding how habits influence anorexia nervosa and its remission
A research study will explore how habitual eating patterns and brain systems keep anorexia nervosa going, and how these habits might change when people recover.
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Flexible ACT: A Pilot Feasibility Trial
A small pilot study is testing a flexible, community-based approach to ACT (Assertive Community Treatment) for people with mental health needs to see if it can be done feasibly in real-world settings.
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Repeated cannabis with different THC/CBD mixes and how it affects pain, cravings, and body chemicals
This project studies how taking cannabis repeatedly, with different THC and CBD amounts, changes pain experiences, potential for abuse, and levels of body chemicals related to the endocannabinoid system in adults.
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Mental Wellness Coordinated Care for Young People with Untreated Psychosis in Mozambique
A program in Mozambique aims to bring early, coordinated care for adolescents and young adults with new psychosis, using evidence-based services to reduce symptoms and improve functioning.
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Supported Employment to Help Youth with Early Psychosis in Uganda
A patient-facing plan to help young people in Uganda with early psychosis find and keep jobs through an adapted IPS program.
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Brain circuits behind overgeneralized fear
This project looks at whether strengthening a small hippocampus area called the dentate gyrus can help adults with PTSD, anxiety, or depression stop reacting to safe situations as if they were dangerous.
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How thalamus activity shapes the teenage brain's thinking center
This project tests whether activity from a deep brain area (the thalamus) during adolescence helps the front part of the brain mature in teens and young adults who may be at risk for schizophrenia.
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Guiding safer, smoother care transitions for ACT clients
A researcher is testing how to reduce hospitalizations after people leave Assertive Community Treatment by identifying which factors predict risk and by understanding how stepdown care affects outcomes.
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Clozapine to reduce violence in schizophrenia
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
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SRLM+ helps HIV clinics reduce stigma to improve care
A structured program helps HIV clinics identify and reduce stigma so people can access prevention and care more easily.
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Adapting a social network program to help end HIV transmission
A short, patient-friendly project is updating a proven social-network approach to help communities reduce new HIV infections and improve prevention and care.
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Astrocytes: how brain support cells help combine brain signals
Scientists are testing whether astrocytes help blend signals from mood- and attention-related brain systems to shape behavior, using advanced imaging and spatial mapping technology.
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Episodic memories of 9/11 and mental health in survivors: NLP analysis of stories from teens and adults
This project uses natural language processing to study how memories of 9/11 affect the mental health of adolescents and adults who lived through the event.
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Harnessing Hormonal Variation to Improve OCD Therapy Outcomes
This grant tests whether timing exposure-based OCD therapy with menstrual-cycle–related hormonal changes can improve brain changes and treatment results for adults with OCD.
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Understanding brain timing patterns in schizophrenia to map how circuits work
A research project will look at brain timing patterns in people with schizophrenia and healthy individuals to understand how brain circuits differ and relate to symptoms.
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Real-time relapse risk scoring for Opioid Use Disorder from trial data
A tool that uses data from opioid treatment trials to produce a real-time score predicting a patient’s risk of relapse in the near future.
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Neural maps in the dentate gyrus and how we build spatial awareness in memory disorders
This NIH grant studies how the brain creates a mental map to help people with Alzheimer’s disease or other memory problems navigate their surroundings.
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Basal forebrain signaling and cognitive flexibility in reversal learning
A physician-scientist-in-training will study how specific brain signals link memory, attention, and learning flexibility in rodent models to better understand symptoms seen in autism and related conditions.
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Social support and dementia risk in sexual and gender minority adults
Looks at how stress and social support relate to thinking skills and brain health in LGBTQ+ adults compared with straight, cisgender adults.
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Partnering with Community Helpers to Improve Prenatal Sleep
A project that tests if trained doulas can help pregnant people sleep better using practical, community-based strategies.
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Sensitive periods for interneuron development affecting cognitive flexibility
This project studies how the development of brain cells that use GABA may shape cognitive flexibility across different ages, with potential implications for conditions like ADHD and Alzheimer’s-related changes.
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Pilot test to expand how we identify suicide risk and connect youth on probation to mental health care
A new project tests a family-focused approach to better detect suicide risk in youth on probation and help them start and stay in behavioral health treatment.
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Block a nerve to help with opioid use disorder when on buprenorphine
A new study will test whether injecting a local anesthetic near a facial nerve (SPG block) as an add-on to buprenorphine treatment can reduce withdrawal symptoms and improve treatment acceptance for people with opioid use disorder who use fentanyl.
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Database and Statistical Core for Conte Center Projects
A dedicated core provides expert data management and statistics support to Conte Center projects to help researchers design studies, manage data securely, and analyze results.
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Clinical Evaluation Core for Bipolar Disorder Studies
A team at a New York psychiatric institute is coordinating recruitment, standardized assessments, and data management for bipolar disorder research to better understand risk factors and outcomes.
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Complex data models to predict suicide risk and understand brain and emotion
Researchers will build advanced models from complex brain and biological data to better understand suicide risk and emotional and cognitive responses, with the goal of improving prediction and prevention for people at risk.
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Neural Causes of Negative Feelings and Memory in Mice: Stopping Suicide Risks with Medication
This grant studies how feelings of hopelessness affect memory in a mouse model and whether a medication can correct those memory changes to reduce suicide risk indicators.
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Understanding gene activity in the brains of people with mood disorders who died by suicide
A study to map which genes are active in brain cells and where they are in the brains of people with mood disorders who attempted or died by suicide, using advanced single-cell and spatial techniques.
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Synaptic changes in mood disorders and suicide risk
This project studies brain Synapse signals in people with mood disorders, including those with a recent suicide attempt, to understand what changes are linked to suicide risk and how ketamine might work.
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Multimodal brain imaging to understand glutamate and memory in suicidal thoughts
A research team will use advanced brain imaging and real-world mood data to learn how glutamate and memory patterns relate to suicide risk and depression, with the goal of better identifying and helping people at risk.
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Stress and mood swings in major depression: how daily stress and ketamine treatment could help prevent suicidal thoughts
A research team is studying how everyday stress affects suicidal thoughts and negative feelings in people with major depression, and whether ketamine could help reduce this risk.
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Administrative Core for Center Leadership and Oversight
This grant funds the Administrative Core of a center to guide scientific priorities, manage resources, and support the researchers and staff over five years.
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Ketamine and brain chemistry in preventing suicide in high-risk depression
A large study will explore how ketamine affects brain chemistry and daily stress responses to help prevent suicide in people with severe depression.
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How gene differences and early adversity shape depression risk in young people
This NIH grant studies why some kids and teens exposed to early stress develop depression and others don’t, looking at how their genes in the brain might influence resilience or vulnerability.
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Aging vs Alzheimer's: brain blood vessels and new brain cells in memory areas
This study looks at how aging and Alzheimer’s disease affect brain blood vessels and new brain cells in a key memory area, and what that means for brain flexibility and aging.
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Finding molecules that help the hippocampus make and keep neurons in aging and Alzheimer's
Researchers are using new lab methods to find proteins and genes that help hippocampus cells make and maintain new neurons in older adults and people with Alzheimer's disease.
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Role of hippocampal dopamine in early life adversity and fear generalization
This grant looks at how early life adversity may change fear generalization in adults by studying dopamine signals in the hippocampus.
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How thalamus–prefrontal brain connections develop during adolescence
Researchers are looking at whether reduced thalamus activity in adolescence changes how the front part of the brain matures, to better understand cognitive problems that can appear in teens and young adults at risk for schizophrenia.
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How early pollution and stress change brain circuits for motivation and memory
This work looks at how early-life exposure to pollution and stress can alter brain circuits that control motivation and working memory for people with ADHD, depression, or similar conditions.
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