Sensitive periods for interneuron development affecting cognitive flexibility
Official title: Sensitive periods for interneuron development supporting cognitive flexibility
Funded at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-11355609 · Data updated 2026-11-12
This project studies how the development of brain cells that use GABA may shape cognitive flexibility across different ages, with potential implications for conditions like ADHD and Alzheimer’s-related changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $562,115 |
| NIH project number | 5R01MH128277-05 |
| Project ID | NIH-11355609 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals in adolescence or adulthood who may be affected by neuropsychiatric conditions involving cognitive flexibility, or healthy volunteers contributing samples for related analyses.
✕Less likely to help
Young children or individuals outside the studied age ranges may not directly benefit from this research.
What this research studies
This study looks at how the maturation of interneurons in the prefrontal cortex influences cognitive flexibility during adolescence and adulthood. By examining the role of PV and SST interneurons and how GABAergic signaling changes over time, researchers aim to map critical periods that shape executive function. The findings could point to windows where interventions might support better cognitive outcomes in neuropsychiatric conditions.
Why it matters
Potential benefit: Understanding when interneuron development most influences cognitive flexibility could guide timing for therapies to support executive function.
How similar studies have gone: Prior work links interneuron development to cognitive control, but this project probes specific developmental windows and their impact on prefrontal circuitry.
Where this research is happening
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New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
New York, United States Active
Researchers
- Principal investigator: Canetta, Sarah E — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Canetta, Sarah E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.