Clozapine to reduce violence in schizophrenia
Official title: 1/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
Funded at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-11411175 · Data updated 2026-11-12
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,235,813 |
| NIH project number | 5R01MH120317-04 |
| Project ID | NIH-11411175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with schizophrenia who are at high risk for violence and can participate in outpatient care across multiple sites.
✕Less likely to help
Individuals without high violence risk or those unable to participate in outpatient follow-up may not benefit.
What this research studies
This trial tests whether clozapine can reduce violent behavior in community-dwelling adults with schizophrenia who are at high risk for violence. It is a 24-week, open-label study conducted at seven sites, coordinated by the New York State Psychiatric Institute, with a parallel-group design and a single rater. Participants will be randomly assigned to receive clozapine or treatment as usual, and the primary outcome is time to a violent act. The study aims to provide clearer evidence about clozapine’s effectiveness in real-world settings beyond hospital care. Outcomes will help guide clinicians on managing violence risk in schizophrenia patients in outpatient environments.
Why it matters
Potential benefit: If successful, the trial could lead to more effective strategies to reduce violence risk for people with schizophrenia and improve safety for patients and communities.
How similar studies have gone: Previous observational and small randomized studies suggested clozapine may reduce aggression, but this large, multicenter trial aims to provide more definitive evidence.
Where this research is happening
-
New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
New York, United States Active
Researchers
- Principal investigator: Girgis, Ragy Ramsis — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Girgis, Ragy Ramsis
Related research
Other NIH-funded projects on the same topics.
-
Clozapine to reduce violent behavior in people with schizophrenia
This compares clozapine with usual care to try to lower the chance of violent acts in people with schizophrenia who are at higher risk.
-
Clozapine to Help Prevent Violence in Schizophrenia
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
-
Clozapine to prevent violence in schizophrenia
This project explores if a medication called clozapine can help reduce violent behavior in people living with schizophrenia.
-
Clozapine to reduce violence in people with schizophrenia
This trial will compare clozapine with usual antipsychotic care to see whether clozapine lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This trial will compare clozapine with usual treatment to see if it lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This project compares clozapine to usual care to find out whether clozapine lowers the chance of violent acts in people with schizophrenia who are at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.