Understanding brain timing patterns in schizophrenia to map how circuits work
Official title: An integrative computational interrogation of circuit dysfunction inschizophrenia via neural timescales
Funded at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-11378116 · Data updated 2026-11-12
A research project will look at brain timing patterns in people with schizophrenia and healthy individuals to understand how brain circuits differ and relate to symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $718,987 |
| NIH project number | 5R01MH129395-05 |
| Project ID | NIH-11378116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with schizophrenia and healthy volunteers whose data are included in large public datasets (e.g., HCP, UK Biobank) and related cohorts.
✕Less likely to help
Healthy individuals without schizophrenia may participate only as part of the reference datasets and may not directly benefit.
What this research studies
This project analyzes large brain-imaging datasets to study intrinsic neural timescales, a measure of how brain regions process information over time, in schizophrenia. Using both data-driven analysis and theory-based models, researchers will examine how these timing patterns relate to genetics, development, and cognitive symptoms. The study will involve secondary analysis of existing datasets from healthy volunteers and patients, with a focus on how timing differences may reflect excitation/inhibition imbalances in cortical circuits. The aim is to build a constrained framework linking genetics, brain circuitry, cognition, and the experience of schizophrenia. The work could guide future biomarkers and targeted interventions by clarifying brain dynamics that accompany the illness.
Why it matters
Potential benefit: Better understanding of brain timing and its links to symptoms could inform future diagnostic tools and personalized treatments for schizophrenia.
How similar studies have gone: Previous work has shown associations between neural timescales and cognitive function, with ongoing efforts to generalize to schizophrenia.
Where this research is happening
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New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
New York, United States Active
Researchers
- Principal investigator: Horga, Guillermo — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Horga, Guillermo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.