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Clinical trials and research at Nationwide Children's Hospital

• 47Clinical trials
• 7Countries

Newest trials

All recruiting trials (47)

• Transauricular Neurostimulation for Abdominal Pain in Teens

  We are testing a head- and ear‑based device to see if it helps teens with abdominal pain from gut-brain disorders.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07798180

• MedMemos: helping families stick to medications after pediatric stem cell transplant

  MedMemos tests a caregiver-focused program to help families of children who had a bone marrow transplant take medications more consistently.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07718204

• Light therapy for children in the pediatric ICU

  This project will try daily bedside light therapy for children aged 4–17 in the pediatric ICU to see how easy it is to deliver and whether patients, families, and staff tolerate it.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07384585

• Food is Medicine program to boost family heart health

  The trial tests whether providing healthy food access plus personalized digital tools and coaching can improve heart health for families with a parent on Medicaid and a 6–11 year old child.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07380243

• AI-based personalized health and self-care support for caregivers of children

  This pilot will test whether the DAPHNE chatbot helps caregivers of children with unmet social needs connect to community resources, stay engaged, and fit into primary care workflows over six months.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07168382

• Caregiver questionnaire on firearm ownership and safety

  We will ask parents and legal guardians of children having surgery at Nationwide Children's Hospital about firearm ownership, storage, access, and safety education to see if common safety practices are followed.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07155083

• Caregiver health literacy in children's surgical care

  This tests whether caregivers' health literacy and social circumstances are linked to caregiver anxiety before outpatient pediatric surgeries and to children's pain after surgery.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07138482

• Digital skills of caregivers of children undergoing surgery

  This project will see if caregivers of children undergoing surgery—especially racial minorities, non-English speakers, and those from low-opportunity neighborhoods—have lower digital skills.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07060326

• Pain Resilience Program to Increase Physical Activity in Teens

  This program will test whether a four-week virtual Pain Resilience Promotion for Youth (PREP-Y) course can help teens ages 12–17 with chronic musculoskeletal pain become more physically active and cope better with their pain.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07049029

• Remote programming and app-based hearing tests for kids and young adults with cochlear implants

  This will test whether remote programming and an iOS app for speech tests work well for teens and young adults (ages 13–20) who use Advanced Bionics cochlear implants.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT07035873

• ACT001 for diffuse intrinsic pontine glioma and H3K27-altered high-grade glioma

  This trial will try the oral drug ACT001 in patients aged 12 months to 39 years with newly diagnosed or progressive/recurrent DIPG or other H3K27-altered high-grade gliomas to see if it is safe and helps control the tumor.

  Recruiting at 9 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT06838676

• Online program to support caregivers of young childhood cancer survivors

  This study is testing an online program to see if it can help caregivers of young childhood cancer survivors feel less stressed and better prepare their kids for school.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06769334

• Combining whole body vibration and serial casting for children with cerebral palsy

  This study is testing if combining whole body vibration with special casts and exercises can help children with cerebral palsy move their ankles better and improve their overall mobility.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06693388

• Interactive intervention for safe firearm storage to prevent youth suicide

  This study is testing a new program to help parents safely store firearms at home to prevent youth suicide among teenagers who have recently left psychiatric hospitals.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio and 1 other locations · NCT06558409

• Tracking movement and health in children 0–5 with LAMA2-related congenital muscular dystrophy

  This project will see how children aged 0–5 with LAMA2-related dystrophy move, breathe, and develop over two years to help find reliable outcome measures for future treatments.

  Recruiting at 13 sites Nationwide Children's Hospital · Los Angeles, California and 13 other locations · NCT06503367

• Intensive Crisis Intervention for teens with suicidal thoughts or behaviors

  This project will try a brief, family-focused Intensive Crisis Intervention to see if it helps 12–17-year-olds with suicidal thoughts or recent attempts reduce suicidal behavior and avoid inpatient psychiatric care.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06476886

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• Improving treatment times for children with status epilepticus

  This study is testing a new way to speed up treatment for children with status epilepticus in hospitals to see if it helps them get their first dose of medicine faster.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06194747

• Comparing cord clamping times for newborns with congenital heart disease

  This study is testing whether clamping the umbilical cord for 30 seconds or 120 seconds after birth helps newborns with congenital heart disease have better health and development.

  Recruiting at 18 sites Nationwide Children's Hospital · Birmingham, Alabama and 20 other locations · NCT06153459

• Feasibility of a new therapy for feeding disorders in infants

  This study is testing a new therapy to help infants with feeding disorders improve their swallowing and reduce their need for tube feeding.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06118697

• Comparing treatments for GERD in infants

  This study is testing three different treatments for GERD in infants in the NICU to see which one helps them feed better and feel more comfortable.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06114836

• Depletion of specific immune cells for stem cell transplantation in young patients

  This study is testing a new way to prepare stem cells for children and young adults with blood cancers by removing certain immune cells to see if it helps them have a safer and more effective transplant from unrelated donors.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06082947

• A program to reduce suicide risk in primary care for adolescents

  This study is testing a new program to see if it can help reduce the risk of suicide in teenagers aged 12-17 who visit their primary care doctors.

  Recruiting at 12 sites Nationwide Children's Hospital · Akron, Ohio and 14 other locations · NCT06018285

• Lifestyle intervention for adolescents and young adults with congenital heart disease

  This study is testing a personalized program to help teenagers and young adults with congenital heart disease get active and improve their heart health.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06003023

• Exploring factors behind pediatric surgery cancellations

  This study is trying to find out why some children's surgeries get canceled by talking to parents, especially those from different backgrounds, to help make the process better in the future.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05939570

• Comparing medications for ADHD in children with autism

  This study is testing two ADHD medications to see which works better for children with autism and how parents can help track their effectiveness.

  Recruiting at 13 sites Phase 4 Nationwide Children's Hospital · Irvine, California and 12 other locations · NCT05916339

• Combining ribociclib and everolimus for treating high-grade gliomas in young patients

  This study is testing if a combination of two drugs, ribociclib and everolimus, can help young patients with high-grade gliomas live longer and feel better after their initial treatment.

  Recruiting at 12 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 19 other locations · NCT05843253

• Genetic profiling for pediatric high-grade glioma treatment eligibility

  This study is testing if genetic testing of brain tumors in children and young adults with high-grade gliomas can help match them to the best treatment options.

  Recruiting at 13 sites Nationwide Children's Hospital · Aurora, Colorado and 21 other locations · NCT05839379

• Infusing immune cells to improve treatment for relapsed pediatric sarcomas

  This study is testing whether adding special immune cells to standard chemotherapy can help children with relapsed or hard-to-treat sarcomas live longer without their cancer getting worse.

  Recruiting at 22 sites Phase 1/2 Nationwide Children's Hospital · South Birmingham, Alabama and 21 other locations · NCT05634369

• Collection of blood samples to study pediatric heart disease

  This study is collecting blood samples from kids with congenital heart disease to see if they can create special cells that help researchers understand and treat heart problems in children better.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05550324

• Comparing two treatments for a heart condition in premature infants

  This study is testing if a special device can help premature infants with a heart condition do better than just using medication.

  Recruiting at 16 sites Nationwide Children's Hospital · Birmingham, Alabama and 23 other locations · NCT05547165

• Using universal donor natural killer cells to treat relapsed or refractory acute myeloid leukemia in young patients

  This study is testing if a new treatment using special immune cells combined with chemotherapy can help young patients with relapsed or hard-to-treat acute myeloid leukemia feel better.

  Recruiting Phase 1/2 Nationwide Children's Hospital · Columbus, Ohio · NCT05503134

• Lower dose corticosteroid treatment for infants with Duchenne Muscular Dystrophy

  This study is testing if a lower dose of corticosteroids can help infants and young boys with Duchenne Muscular Dystrophy improve their movement skills while causing fewer side effects than a higher dose.

  Recruiting at 4 sites Phase 4 Nationwide Children's Hospital · Chicago, Illinois and 3 other locations · NCT05412394

• Program to improve sleep and reduce suicidal behavior in adolescents

  This study is testing a new program to help teenagers who have trouble sleeping and are feeling suicidal, to see if it can improve their sleep and reduce their suicidal thoughts.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05390918

• Treatment of pediatric adamantinomatous craniopharyngioma with MEKTOVI

  This study is testing if a new drug called MEKTOVI can help young patients with a tough brain tumor called adamantinomatous craniopharyngioma feel better and manage their condition.

  Recruiting at 10 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 9 other locations · NCT05286788

• Lutathera treatment for recurrent high-grade brain tumors

  This study is testing if Lutathera can safely help children and young adults with recurring high-grade brain tumors that show certain markers on scans.

  Recruiting at 2 sites Phase 1/2 Nationwide Children's Hospital · Aurora, Colorado and 3 other locations · NCT05278208

• Reversing inflammation in children with sepsis-induced organ dysfunction

  This study is testing if a drug called anakinra can help children with sepsis-induced organ problems by reducing inflammation.

  Recruiting at 29 sites Phase 2/3 Nationwide Children's Hospital · Birmingham, Alabama and 31 other locations · NCT05267821

• Using ACTEMRA to treat pediatric brain tumors

  This study is testing if the drug ACTEMRA can help children and young adults with a specific type of brain tumor feel better and improve their quality of life.

  Recruiting at 13 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 13 other locations · NCT05233397

• Effects of a cellphone app on young drivers' behavior

  This study tests whether a cellphone-blocking app can help young drivers aged 18-24 drive safer by reducing their phone use while driving.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05163119

• Using cabozantinib to prevent recurrence in high-risk pediatric solid tumors

  This study is testing if the drug cabozantinib can help prevent high-risk pediatric solid tumors, like neuroblastoma and sarcoma, from coming back after treatment.

  Recruiting at 6 sites Phase 2 Nationwide Children's Hospital · Birmingham, Alabama and 5 other locations · NCT05135975

• PEP-CMV vaccine for treating pediatric brain tumors

  This study is testing a new vaccine for kids with certain types of brain tumors to see if it can help them feel better when used with a common chemotherapy drug.

  Recruiting at 10 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 12 other locations · NCT05096481

• Using donor T-cells to treat severe adenovirus infections

  This study is testing if T-cells from related donors can help people with severe adenovirus infections who have weakened immune systems due to organ transplants or cancer.

  Recruiting Phase 1/2 Nationwide Children's Hospital · Columbus, Ohio · NCT04722029

• Using Larotrectinib for Children with Newly Diagnosed High-Grade Glioma with NTRK Fusion

  This study is testing if a new drug called larotrectinib can help children with a specific type of brain cancer called high-grade glioma that has an NTRK fusion.

  Recruiting at 20 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 20 other locations · NCT04655404

• Evaluating a new type of vascular graft for heart surgery in children

  This study is testing a new type of heart surgery graft for children to see if it is safe and works well for their needs.

  Recruiting Phase 2 Nationwide Children's Hospital · Columbus, Ohio · NCT04467671

• Locoregional injections of expanded natural killer cells for high grade glioma

  This study is testing if giving special immune cells directly to patients with tough brain tumors can be safe and help them feel better.

  Recruiting Phase 1 Nationwide Children's Hospital · Columbus, Ohio · NCT04254419

• Imaging blood flow in patients with peripheral artery disease

  This study is testing how imaging blood flow in the legs can help doctors understand and improve treatment for people with peripheral artery disease who are having surgery to restore blood flow.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT03622359

• Exploring the genetics behind congenital heart disease

  This study is trying to find out the genetic reasons behind congenital heart disease by looking at the DNA of people with the condition and their families.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT01192048

Quick answers

How many clinical trials run by Nationwide Children's Hospital are recruiting right now?

47, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (47 trials), Canada (9 trials), Australia (7 trials), Germany (5 trials), New Zealand (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 4, Phase 4: 2, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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