Sponsor or institution
Clinical trials and research at La Jolla Institute for Immunology
As of November 12, 2026, Find a Trial lists 91 NIH-funded research projects at this institution, with $71.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 91NIH research projects
NIH-funded research (newest 40 of 91)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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HIPC Data Coordinating Center
A coordinated center to share and standardize immune-system data from many studies so researchers can learn more quickly about human immune responses.
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Respiratory pathogen–specific T cell signatures after vaccination, infection, and treatment
A research effort to map how immune T cells respond to respiratory infections and vaccines, with potential to guide better vaccines and treatments for conditions like covid-19 and pertussis.
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Role of MAIT Cells in Primary Biliary Cholangitis (PBC)
This grant investigates how MAIT immune cells contribute to the autoimmune liver disease PBC and what that means for future therapies.
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Dietary nudges that shape gut and liver immune guardians
A research project will explore how what you eat affects a special group of immune cells in the gut and liver that protect you from infections and cancer.
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Cancer Epitope Database and Analysis Resource for Precision Oncology
A cancer-epitope database and analysis tools to help doctors and patients by advancing personalized cancer diagnostics and vaccines.
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TET-DNMT-ASXL1-OGT axis and clonal hematopoiesis in cancer and aging
A long-running NIH project is exploring how specific gene mutations alter blood cell development and contribute to cancer, aging, and inflammation in people.
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Immune cell gene activity map across diverse ancestries
A large NIH project will build a reference map showing how genetic differences affect gene activity in immune cells from people of diverse ancestral backgrounds.
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Data Management and Analysis Core for sharing and analyzing immunology data
A centralized data hub helps researchers manage, analyze, and share immunology data from multiple projects while keeping donor information protected.
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Single-cell map of lung tissue memory T cells that react to respiratory infections
A research team will study human lung memory T cells to build a detailed map of their genes, epigenetic marks, and TCRs in response to common respiratory pathogens.
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Immune signatures of TB-specific T cells over time in adults with TB or latent infection
A patient-focused look at how TB-specific immune cells change during treatment or in latent infection, to help predict outcomes and tailor care.
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How our immune system keeps a memory of vaccines and infections over time
A long-term study to understand how T cells remember SARS-CoV-2 vaccines and infections, and how this compares with common cold coronaviruses.
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Sequencing Core supports study of immune cells in lung infections
A core sequencing grant helps researchers profile immune cells from people with lung infections to understand how T cells respond.
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Clinical Core for immune signatures in respiratory pathogens
A Clinical Core at a major immunology institute helps collect and manage human samples and data from people, so scientists can learn how T cells respond to respiratory infections.
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Administrative Core for a multi-project immunology program (HIPC)
A central administrative grant supports a national immunology program working on coronaviruses by coordinating projects, reporting to NIH, and managing resources.
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Respiratory pathogen–specific T cell signals after infection and vaccination
A study to map how immune T cells respond to flu, RSV, coronaviruses, TB, and pertussis after infection or vaccination, to help guide better vaccines and treatments.
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Understanding how human genetic variations shape disease through 3D genome organization
This NIH grant studies how genetic differences in people influence disease by looking at how DNA folds in 3D space inside cells.
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What affects protective memory immune cells in the nose and throat
Researchers will compare how age, smoking, diabetes, and vaccination change tissue-resident memory T cells in the upper airway of people having routine surgery.
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How immune memory adapts to new COVID-19 variants
Researchers are tracking how people's immune systems remember and respond to COVID-19 after different combinations of vaccinations and infections.
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How long-lived germinal centers affect immune memory and mucosal protection
Looking at whether long-lasting germinal centers help people keep stronger antibody and T-cell memory and better nose-and-throat protection after SARS‑CoV‑2 infection or COVID vaccination.
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Central clinical hub for collecting patient samples
This project collects and stores blood, nasal swabs, lymph node tissue, and related samples from adults to support COVID-19 immune research.
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Immune memory after COVID-19, vaccination, and other respiratory infections
This project looks at how people's immune systems remember COVID-19, vaccines, and similar respiratory infections to help improve protection.
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Understanding how immune cells in lymphoid tissue behave in human SLE and how treatments affect them
This grant studies how immune cells in lymphoid tissues respond in people with systemic lupus erythematosus and how therapies change those responses.
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Protecting mothers and babies from Zika during pregnancy
A new vaccine approach aims to help pregnant people protect their babies from Zika infection that crosses the placenta.
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mRNA approaches to create stronger, broader, and longer-lasting protection against HIV
This project aims to use mRNA vaccine methods to help the immune system make broader, longer-lasting antibodies that could protect against many HIV strains.
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TET enzymes and mobile DNA activity in aging
Seeing whether loss of TET enzyme function lets mobile DNA elements become active and trigger inflammation in older adults.
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How key molecular switches control T cell behavior
This project is learning how specific gene-regulating proteins in T cells change their ability to fight cancer so treatments like CAR T and checkpoint drugs work better for patients.
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LSP1 gene in T cells and its role in inflammatory bowel disease
This project looks at whether lower levels of the LSP1 gene in certain T cells push immune cells to drive worse inflammatory bowel disease in people with IBD.
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Understanding how the body fights mumps: mapping human antibodies to mumps surface proteins
Researchers are studying how people’s antibodies recognize and target mumps surface proteins to improve protection from the vaccine and natural infection.
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Mapping how aging changes the molecular switches in T cells
Using gene-editing tools to find which molecular switches in CD8 T cells stop working with age, with the goal of helping older adults keep stronger immune responses.
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Predicting how long and how broadly flu vaccines protect people
This project uses immune and genetic data to predict how long and how broadly flu vaccines protect people.
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Investigating how sensitization to a common fungus affects asthma development
This study is looking at how the Alternaria fungus affects people with asthma, trying to find out why some people are more sensitive to it than others, which could help us understand asthma triggers better and find new ways to treat it.
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Identifying immune responses to pneumonia-causing bacteria
This study is looking at how our immune system, especially T cells, responds to bacteria that can cause pneumonia, and it's for people who have pneumonia as well as those who haven't been sick but might have been exposed to these germs.
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Identifying key parts of viruses that could cause pandemics
This study is looking for common parts of certain viruses that could help create vaccines or treatments for future pandemics, so that people can be better protected against illnesses like COVID-19 and others.
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Maps of immune cell gene activity in people from diverse backgrounds
Collecting gene and epigenetic data from immune cells of people from diverse ancestries to better explain why autoimmune disease risk differs between groups.
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How changes in TET, DNMT3A, ASXL1 and OGT affect blood stem cell clones and cancer risk
This project looks at how specific gene changes in blood stem cells may cause clonal blood cell growth and raise the risk of cancer and inflammation for people with those mutations.
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Why T cells get 'tired' inside tumors
This work looks at how immune T cells become 'exhausted' in tumors so treatments like CAR‑T and checkpoint blockers can work better for people with cancer.
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How human genetic differences change gene activity through the 3D folding of DNA
This project looks at how genetic differences in people alter the three-dimensional folding of DNA in cells to help explain links to autoimmune diseases and cancers.
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Investigating immune responses to SARS-CoV-2 in healthy and cancer patients
This study is looking at how certain immune cells called T cells react to the COVID-19 virus in both healthy people and those with cancer, to see how long their protection lasts compared to antibodies, and it could help us find ways to boost our immune defenses against the virus.
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Helping the immune system make stronger antibodies against HIV
Testing slow-release vaccine approaches to help people's immune systems produce stronger, broader antibodies that can neutralize HIV.
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Understanding and Preventing Side Effects of Cancer Immunotherapy
This research looks at a natural small molecule called LPC 18:2 to help prevent or reduce severe side effects in cancer patients receiving powerful immune-boosting treatments.
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