Clinical Core for immune signatures in respiratory pathogens
Official title: Clinical Core
Funded at La Jolla Institute for Immunology · NIH-11398850 · Data updated 2026-11-12
A Clinical Core at a major immunology institute helps collect and manage human samples and data from people, so scientists can learn how T cells respond to respiratory infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 15, 2015 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $328,279 |
| NIH project number | 5U19AI118626-12 |
| Project ID | NIH-11398850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults who have had or been exposed to respiratory pathogens and who can donate high-quality clinical samples and donor information.
✕Less likely to help
People who cannot provide consent, have certain health conditions restricting participation, or whose samples cannot be collected or stored safely may not benefit.
What this research studies
This core coordinates human subjects documentation, staff training, sample collection and storage, and data management across collaborating sites. It ensures donor information is accurate and samples are validated for research use. Researchers use the data to build immune signatures for T cells responding to pathogens like SARS-CoV-2, flu, pertussis, tuberculosis, and fungi. By keeping high-quality samples and precise records, the program aims to enable reliable insights into how the immune system fights respiratory infections.
Why it matters
Potential benefit: If successful, this work could improve understanding of immune responses to respiratory pathogens and inform better vaccines and therapies.
How similar studies have gone: Similar clinical cores have supported multi-pathogen immune studies by ensuring sample quality and data integrity, enabling robust immune profiling.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Vijayanand, Pandurangan — La Jolla Institute for Immunology
- Study coordinator: Vijayanand, Pandurangan
Related research
Other NIH-funded projects on the same topics.
-
HIPC Data Coordinating Center
A coordinated center to share and standardize immune-system data from many studies so researchers can learn more quickly about human immune responses.
-
Respiratory pathogen–specific T cell signatures after vaccination, infection, and treatment
A research effort to map how immune T cells respond to respiratory infections and vaccines, with potential to guide better vaccines and treatments for conditions like covid-19 and pertussis.
-
Role of MAIT Cells in Primary Biliary Cholangitis (PBC)
This grant investigates how MAIT immune cells contribute to the autoimmune liver disease PBC and what that means for future therapies.
-
Dietary nudges that shape gut and liver immune guardians
A research project will explore how what you eat affects a special group of immune cells in the gut and liver that protect you from infections and cancer.
-
Cancer Epitope Database and Analysis Resource for Precision Oncology
A cancer-epitope database and analysis tools to help doctors and patients by advancing personalized cancer diagnostics and vaccines.
-
TET-DNMT-ASXL1-OGT axis and clonal hematopoiesis in cancer and aging
A long-running NIH project is exploring how specific gene mutations alter blood cell development and contribute to cancer, aging, and inflammation in people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.