Immune signatures of TB-specific T cells over time in adults with TB or latent infection
Official title: Longitudinal Analysis of Immune Signatures (IMS) of M. tuberculosis-specific T cells
Funded at La Jolla Institute for Immunology · NIH-11398857 · Data updated 2026-11-12
A patient-focused look at how TB-specific immune cells change during treatment or in latent infection, to help predict outcomes and tailor care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 15, 2015 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $328,279 |
| NIH project number | 5U19AI118626-12 |
| Project ID | NIH-11398857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with active pulmonary TB starting treatment or adults with latent TB infection.
✕Less likely to help
People without TB infection or those not enrolled in the specified cohorts may not benefit from these findings.
What this research studies
This project follows adults with active TB or latent TB infection to map how their TB-specific CD4 T cells respond over time using established peptide pools, cytometry, and single-cell RNA sequencing. By tracking immune signatures during therapy, researchers aim to find markers that predict how well someone will respond to treatment. The study will compare active TB patients starting therapy with individuals who have latent infection, exploring differences in immune patterns and T cell receptors. Results could inform better diagnostic and monitoring tools for TB in diverse patient populations.
Why it matters
Potential benefit: If successful, the work could lead to more precise biomarkers for treatment response and progression risk in TB patients.
How similar studies have gone: Previous work has shown that TB-specific T cell signatures can reflect disease status, but longitudinal links to treatment outcomes are still being explored.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Peters, Bjoern — La Jolla Institute for Immunology
- Study coordinator: Peters, Bjoern
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.