Why T cells get 'tired' inside tumors
Signal transduction and gene induction in lymphocytes
['FUNDING_R01'] · LA JOLLA INSTITUTE FOR IMMUNOLOGY · NIH-11170744
This work looks at how immune T cells become 'exhausted' in tumors so treatments like CAR‑T and checkpoint blockers can work better for people with cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LA JOLLA INSTITUTE FOR IMMUNOLOGY (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11170744 on ClinicalTrials.gov |
What this research studies
Researchers are examining the molecular signals that switch genes on and off in T cells, focusing on key proteins called NFAT and AP‑1. They combine studies in mouse models with analysis of human tumor and blood samples to see how these signals drive T cell exhaustion. By comparing the programs that drive strong anti‑tumor activity versus those that dampen responses, they aim to identify targets to keep T cells active and form long‑lasting tumor memory. The findings could point to new drugs or ways to improve existing immunotherapies.
Who could benefit from this research
Good fit: Ideal participants would be people with cancer—especially those with solid tumors—who are receiving or may receive immunotherapy and who can donate blood or tumor samples or join related clinical protocols.
Not a fit: People without cancer or with conditions unrelated to T cell dysfunction are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could make immunotherapies more effective against solid tumors and reduce cancer recurrence.
How similar studies have performed: Previous immunotherapies like CAR‑T and PD‑1 blockade have helped many patients, and laboratory studies targeting exhaustion pathways show promise, but translating NFAT/AP‑1–based strategies into widely effective human treatments remains limited so far.
Where this research is happening
LA JOLLA, UNITED STATES
- LA JOLLA INSTITUTE FOR IMMUNOLOGY — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOGAN, PATRICK — LA JOLLA INSTITUTE FOR IMMUNOLOGY
- Study coordinator: HOGAN, PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.