Immune cell gene activity map across diverse ancestries
Official title: Research Resources: Epigenomic and Transcriptomic Profile of Human Immune Cells
Funded at La Jolla Institute for Immunology · NIH-11414898 · Data updated 2026-11-12
A large NIH project will build a reference map showing how genetic differences affect gene activity in immune cells from people of diverse ancestral backgrounds.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2014 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,301,799 |
| NIH project number | 5R24AI108564-11 |
| Project ID | NIH-11414898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with autoimmune diseases or those with diverse ancestral backgrounds contributing samples and data.
✕Less likely to help
Participants not contributing samples or data may not directly benefit.
What this research studies
This project creates detailed profiles of how gene variants influence immune cell behavior in people from different ancestries. It focuses on transcriptomes and how variants change gene expression in immune cells, helping us understand autoimmune diseases better. The data will be made available to researchers and clinicians so they can relate genetic risk to immune function in diverse patient groups.
Why it matters
Potential benefit: Could improve understanding of autoimmune disease risks and inform personalized approaches based on ancestry and immune cell biology.
How similar studies have gone: Preliminary multi-ancestry studies have shown that ancestry-specific genetic effects exist and can influence immune cell function.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Vijayanand, Pandurangan — La Jolla Institute for Immunology
- Study coordinator: Vijayanand, Pandurangan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.