Understanding how immune cells in lymphoid tissue behave in human SLE and how treatments affect them
Official title: Understanding lymphoid tissue immunology in human SLE and the impact of therapeutic interventions
Funded at La Jolla Institute for Immunology · NIH-11347920 · Data updated 2026-11-12
This grant studies how immune cells in lymphoid tissues respond in people with systemic lupus erythematosus and how therapies change those responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 2, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $929,095 |
| NIH project number | 1R01AI198773-01 |
| Project ID | NIH-11347920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with systemic lupus erythematosus who are undergoing treatment and willing to provide nasal swab samples over multiple time points.
✕Less likely to help
Patients not willing or able to provide repeated nasal swabs or who do not have SLE may not benefit from this study.
What this research studies
Researchers will use a minimally invasive nasal swab method to collect lymphoid tissue samples from people with SLE and apply advanced flow cytometry and gene profiling to map immune cell changes over time. This approach goes beyond blood tests to directly examine the immune environment in lymphoid tissues, which are key in disease activity. The study design emphasizes longitudinal sampling so we can see how treatments influence tissue-level immune responses across multiple visits.
Why it matters
Potential benefit: If successful, this work could lead to more precise monitoring of how therapies work in SLE and help tailor treatments to individual patients.
How similar studies have gone: Early studies using tissue-level immune profiling in humans have shown meaningful insights that blood alone cannot provide, supporting this approach as promising.
Where this research is happening
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La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Crotty, Shane P — La Jolla Institute for Immunology
- Study coordinator: Crotty, Shane P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.