Sponsor or institution
Clinical trials and research at Cleveland Clinic Lerner Com-Cwru
As of November 12, 2026, Find a Trial lists 577 NIH-funded research projects at this institution, with $306.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 577NIH research projects
NIH-funded research (newest 40 of 577)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
Susceptibility-based MRI biomarkers for multiple sclerosis
A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
-
Population genomics in peripartum cardiomyopathy
A gene-focused study to understand why some women develop heart failure around and after pregnancy, with an emphasis on African ancestry.
-
Broad antiviral therapy by targeting a key enzyme in nucleotide synthesis
A plan to block a human enzyme that many viruses need, with the aim of creating a broad-spectrum antiviral treatment for infections like SARS-CoV-2, influenza, and HSV-1.
-
Cellular-level Vascular Oculomics for Monitoring Systemic Vascular Health
A multi-site project using eye imaging and AI to monitor blood vessel health in people, with devices and software developed across four clinical sites.
-
Cellular-level Eye Signals to Track Vascular Health
A multi-site project aims to create and test portable imaging devices and AI tools that can monitor blood vessel health through the eye.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Bone marrow immune cells and glioma progression in teens and young adults
A study in adolescents and young adults with brain tumors looks at how immune cells from bone marrow may influence the progression from low-grade to high-grade gliomas.
-
Protein phosphoribosylation in herpesvirus infections and viral protein function
A small NIH-funded project will explore a tiny chemical change on viral proteins during herpesvirus infection to understand how these viruses replicate and spread.
-
Early-life malaria exposure and vaccine protection in Kenyan infants
This project looks at how infections early in life affect how well malaria vaccines work in babies in Kenya.
-
Impact of early-life malaria exposures on vaccine protection in Kenyan infants
This grant tests how early malaria exposures affect how well malaria vaccines work in young children in Kenya.
-
First-in-class complement inhibitor for blood diseases that damage red blood cells
A new, targeted therapy being developed to help people with blood diseases like PNH and AIHA by blocking the immune system’s complement attack on red blood cells.
-
Adopting and Sustaining a Cervical Precancer Treatment in El Salvador
This project explores how a low-resource setting can implement and keep using a cervical precancer treatment to help women in El Salvador.
-
Cleveland COPE-AKI Clinical Center: Better Care After Acute Kidney Injury
A new program helps people who survived a hospital-based acute kidney injury receive more coordinated follow-up care to prevent kidney and health problems later.
-
Endometrial Blood-Clotting Factors and Heostasis in Heavy Menstrual Bleeding
A clinician-scientist study will explore how endometrial blood-clotting proteins in menstrual blood relate to heavy menstrual bleeding in people who menstruate.
-
Immune 'brakes' on blood cells in mild (symptom-free) malaria
This project looks at whether certain immune 'brakes' on blood cells help explain why some children carry malaria parasites without getting sick.
-
Alzheimer’s-related dementia after COVID-19: how SARS-CoV-2 affects the brain and potential drug repurposing
This research looks at how COVID-19 may contribute to dementia by studying brain inflammation, blood vessel injury, and virus-host interactions, with the goal of finding existing drugs that could help.
-
Cervical cancer screening with a portable HPV test
A new, battery-powered, point-of-care HPV test is being tested to see if it can quickly and reliably screen people for cervical cancer risk outside traditional labs, in places like safety-net clinics and in El Salvador.
-
IL-33 and thymus recovery after transplant with ATG lymphoablation
A new study aims to understand how a molecule called IL-33 helps the thymus rebuild the immune system after transplant patients receive lymphocyte-depleting therapy.
-
Metaorganismal Endocrinology in Cardiometabolic Disease
Researchers are testing a way to target gut microbes and their products to help people with obesity, diabetes, heart disease, and cancer.
-
Aplastic Anemia Registry to Understand How Immune and Genetic Discoveries Affect Disease
A collaborative registry study to learn how genetic background and immune factors influence aplastic anemia and related bone marrow failure conditions in patients.
-
Reducing bacteria inside oral cancer tumors to boost immune response
In people with head and neck cancer, this study tests whether lowering bacteria in tumors can help the immune system fight the cancer better.
-
Aligning T-cell biology with CAR design to improve lymphoma therapy
A new NIH grant is exploring smarter CAR-T cell designs to make lymphoma treatment more durable and safer for patients.
-
Epigenetic control of optic nerve head cells in glaucoma
This grant aims to understand how age and eye pressure change specific brain-like cells at the optic nerve head to influence glaucoma progression and retinal cell survival.
-
Mitochondrial Gasdermin-D and neuroinflammation in Alzheimer’s and related diseases
This grant studies how mitochondrial gasdermin-D drives brain inflammation and nerve cell damage in Alzheimer’s-type conditions and related synucleinopathies.
-
Metabolic drivers of donor-specific antibodies in transplantation
This grant studies why donor antibodies appear after transplantation and how metabolism in the body influences this process, with the goal of preventing antibody-related graft loss.
-
Gut bacteria and Tuft-2 cells linked to early colorectal cancer risk in young Black Americans
This grant aims to understand how gut microbes and Tuft-2 cells may predict aggressive colon adenomas in young Black adults who develop colorectal cancer.
-
KUH-TN Networking Core for a statewide translational training network
A nationwide-style training network is being built in Ohio to connect TL1 and other early-career trainees with mentors, peers, and alumni to accelerate career development in translational science.
-
Administrative Core to support a cross-institution training network for kidney, urology, and hematology research
A network-wide administrative core helps train and connect researchers across Cleveland and Columbus to advance kidney, urology, and blood disease science.
-
Cleveland Kidney, Urology and Hematology Training Network (KUH-TN) for Future Clinician-Scientists
A national network provides mentored research training for clinicians and researchers in kidney, urology, and hematology to nurture the next generation of experts.
-
Alcohol, gut health, and butyrate: a new approach to reduce pain and withdrawal effects
This research looks at how the gut microbiome and a key molecule called butyrate might influence pain, alcohol withdrawal, and brain inflammation in people who struggle with alcohol use and chronic pain.
-
Role of VISTA in AML immune evasion
A companying therapy goal is to block a specific immune brake (VISTA) to help the immune system fight acute myeloid leukemia.
-
Cross-Training Core for Cancer translational science
A cross-training program helps scientists from biology and physics work with doctors to move cancer discoveries from the lab to patient care.
-
Translational and Clinical Correlates Core for ROBIN Program
A dedicated core provides advanced sample handling, high-tech profiling, and expert data analysis to support ROBIN Program studies and clinical trials.
-
Molecular clues to how head and neck cancer responds to radiation and immunotherapy
This project studies why head and neck cancers stop responding to radiation and immune therapy, using patient samples and data to uncover biological clues that could guide better treatments.
-
Transcriptional Dynamics and Timing of Radiation Therapy (Project 2)
A researcher team at a major cancer center is exploring how cells change their gene activity over time during radiation treatment to understand why some tumors respond differently.
-
Genetic and Immune Factors in Squaring the Room: Sacituzumab plus Radiation for Bladder Cancer
A study aims to understand why combining sacituzumab with radiation helps some bladder cancer patients more than others, with the goal of making bladder-sparing therapy more effective.
-
Molecular Characterization Trial for bladder cancer and head & neck cancer patients
A patient-friendly program that collects tissue and data from bladder cancer and head & neck cancer patients before, during, and after radiotherapy to guide personalized treatments with radiation and targeted drugs.
-
Administrative Core for ROBIN Center in Cancer Science
A centralized administrative hub is created to lead and coordinate ROBIN center activities across three institutions to support cancer research and clinical trials.
-
Radiation-based cancer therapy: how biology and the tumor environment affect treatment (cross-training program)
A multi-institution program trains cancer researchers to translate lab discoveries about bladder cancer and other cancers into better radiation therapies for patients.
-
KSHV vaccine platforms and a chimeric mouse virus for in vivo testing
Researchers are developing three vaccine approaches against Kaposi's sarcoma–associated herpesvirus (KSHV) and a mouse surrogate virus to test them in live animals, aiming to prevent disease in people at risk.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.