Cellular-level Vascular Oculomics for Monitoring Systemic Vascular Health
Official title: Cellular-level Vascular Oculomics (CVO) for monitoring systemic vascular health
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11611210 · Data updated 2026-11-12
A multi-site project using eye imaging and AI to monitor blood vessel health in people, with devices and software developed across four clinical sites.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 21, 2026 |
| Project end | September 13, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,628,117 |
| NIH project number | 3OT2OD038128-02S1 |
| Project ID | NIH-11611210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who may have or be at risk for systemic vascular issues or Alzheimer’s disease, particularly those enrolled at the participating sites.
✕Less likely to help
Individuals not undergoing eye imaging or not matching the study’s inclusion criteria may not benefit.
What this research studies
This project develops four new imaging devices and real-time software to capture and analyze eye vasculature, helping researchers track systemic vascular health. It will use AI to annotate biomarkers in images and create a shared dataset across Stanford, Indiana, Cleveland Clinic, and Mount Sinai. Over three years, clinicians and engineers will collaborate to image both healthy and diseased subjects, build normative data, and refine image stabilization and distortion correction. The goal is to enable early detection of vascular issues that relate to conditions like Alzheimer’s disease and related AI-enabled diagnostics.
Why it matters
Potential benefit: If successful, it could provide a noninvasive way to monitor vascular health and potentially identify early indicators of systemic diseases.
How similar studies have gone: Previous efforts show that eye imaging and AI annotation can reveal biomarkers related to vascular health, though this project aims to scale and standardize across multiple sites.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Fawzi, Amani a — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Fawzi, Amani a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.