Susceptibility-based MRI biomarkers for multiple sclerosis
Official title: Susceptibility based MRI biomarkers for multiple sclerosis
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11631162 · Data updated 2026-11-12
A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $549,500 |
| NIH project number | 1R56NS146394-01A1 |
| Project ID | NIH-11631162 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults suspected of having or diagnosed with multiple sclerosis who can undergo MRI and follow-up assessments.
✕Less likely to help
Patients unable to undergo MRI or participate in long-term follow-up may not benefit from this study.
What this research studies
This project seeks to validate MRI markers called central vein sign and paramagnetic rim lesions to improve MS diagnosis and prognosis. Researchers will use a high-resolution 3D imaging sequence across multiple centers to see how well these markers identify MS and predict outcomes over time. The study involves people at risk for or diagnosed with MS who will undergo MRI scans and follow-up visits to track disease progression.
Why it matters
Potential benefit: If successful, the biomarkers could lead to earlier and more accurate MS diagnosis and better monitoring of disease progression.
How similar studies have gone: Previous work suggests CVS and PRL are promising biomarkers, but long-term multi-center validation is needed.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Ontaneda, Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ontaneda, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.