Radiation-based cancer therapy: how biology and the tumor environment affect treatment (cross-training program)
Official title: Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11416560 · Data updated 2026-11-12
A multi-institution program trains cancer researchers to translate lab discoveries about bladder cancer and other cancers into better radiation therapies for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 14, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,518,487 |
| NIH project number | 5U54CA274513-05 |
| Project ID | NIH-11416560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with bladder cancer or other cancers where radiation therapy is a key treatment option, and where translational research could influence future care.
✕Less likely to help
Non-therapy-focused basic research without direct implications for radiation treatment in humans may have limited direct patient benefit.
What this research studies
This program supports cross-training between cancer biologists, physicians, and medical physicists to bridge lab ideas and clinical care in radiation-based treatments. It focuses on understanding how tumor biology and the surrounding environment influence treatment effectiveness, and uses this knowledge to inform smarter combination therapies. Participants include scientists and clinicians working together to develop and test translational strategies that could lead to more effective, personalized radiation regimens for patients with bladder cancer and other cancers.
Why it matters
Potential benefit: If successful, patients could see more effective radiation therapies with better outcomes and fewer side effects.
How similar studies have gone: Past translational programs have shown that integrated training can accelerate moving lab findings toward clinical trials, though outcomes vary by project.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Chan, Timothy an-Thy — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Chan, Timothy an-Thy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.