Transcriptional Dynamics and Timing of Radiation Therapy (Project 2)
Official title: Project 2: Transcriptional Dynamics and Temporal Reprogramming During Radiation Treatment
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11416567 · Data updated 2026-11-12
A researcher team at a major cancer center is exploring how cells change their gene activity over time during radiation treatment to understand why some tumors respond differently.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 14, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $178,293 |
| NIH project number | 5U54CA274513-05 |
| Project ID | NIH-11416567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancer undergoing radiation therapy or those whose tumors have similar molecular characteristics studied in this project.
✕Less likely to help
Patients not receiving radiation therapy or whose tumor biology does not match the studied profiles may see no direct benefit.
What this research studies
This project looks at how radiation therapy affects cancer cells at the level of gene activity and timing. The researchers plan to map transcriptional changes as treatment progresses to identify potential moments to tailor therapy. The goal is to inform personalized radiation strategies that could improve effectiveness and reduce side effects for patients. The study is conducted using human cancer biology concepts and aims to translate these findings into clinical benefit.
Why it matters
Potential benefit: If successful, results could lead to more precise radiation plans personalized to a patient’s tumor biology.
How similar studies have gone: Related work in cancer biology and radiation research has shown that timing and molecular changes can influence treatment responses, though specific temporal transcriptional dynamics during RT are still being explored.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Scott, Jacob Gardinier — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Scott, Jacob Gardinier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.