Cervical cancer screening with a portable HPV test
Official title: CHAMP: Cervical Cancer Prevention Using HPV Testing with a Mobile Testing Platform
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11449416 · Data updated 2026-11-12
A new, battery-powered, point-of-care HPV test is being tested to see if it can quickly and reliably screen people for cervical cancer risk outside traditional labs, in places like safety-net clinics and in El Salvador.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 7, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $574,063 |
| NIH project number | 1R01CA299083-01A1 |
| Project ID | NIH-11449416 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals due for cervical cancer screening, particularly those in safety-net settings and populations in El Salvador and Cleveland.
✕Less likely to help
Patients unlikely to benefit are those not due for screening or those in settings where the test cannot be deployed.
What this research studies
This project tests a field-deployable HPV testing device built with an industry partner to bring rapid results to settings that may not have centralized labs. Researchers will compare the new platform to an established lab assay using archived tissue samples, and also assess how well it works in real-world clinics in El Salvador and Cleveland. They will look at how easy the workflow is, whether patients accept the testing approach, and whether it could be cost-effective compared with current screening practices. The goal is to reduce loss to follow-up and improve timely detection of high-grade cervical precancer through accessible testing. If successful, the platform could enable broader, faster screening in underserved populations.
Why it matters
Potential benefit: It could make cervical cancer screening faster and more accessible, especially in clinics without strong lab infrastructure.
How similar studies have gone: Previous work showed high sensitivity for detecting high-grade precancer with related assays, and this study builds on that by validating a field-ready device.
Where this research is happening
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Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Cremer, Miriam — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Cremer, Miriam
Related research
Other NIH-funded projects on the same topics.
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Community and digital tools to reduce HPV and cervical cancer burden
A nurse or health team will test a community-based, digital strategy to help girls and young women, especially in rural areas, get HPV vaccination and cervical cancer prevention services.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
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HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
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Hybrid approach to boost cervical cancer screening in Uganda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.