Sponsor or institution
Clinical trials and research at Children's Hospital of Los Angeles
As of November 12, 2026, Find a Trial lists 128 NIH-funded research projects at this institution, with $88.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 128NIH research projects
NIH-funded research (newest 40 of 128)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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UMPIRE Protocol: A Urologic Plan to Protect Kidneys in Young Children with Spina Bifida
A coordinated urologic plan is being tested to preserve kidney health in young children with spina bifida by standardizing care and collecting data across multiple sites.
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National Spina Bifida Patient Registry, Component B
This project continues collecting and sharing information from people with spina bifida to improve care and outcomes.
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NEUROG3's role in forming pancreatic progenitor cells
Researchers are studying how a NEUROG3 gene flaw in patient-derived stem cells affects the development of pancreas cells that can later become insulin-producing cells.
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Point-of-care brain MRI for kids with head injuries
A fast, bedside MRI test using a portable low-field machine for children with head trauma to help doctors decide next steps without exposing them to radiation.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
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Brain and Cognitive Development in kids exposed to alcohol before birth
This grant would study how prenatal alcohol exposure affects brain and thinking skills in children and teens from a South African birth cohort, using follow-up brain imaging and cognitive tests.
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Patient-ventilator Asynchrony in Critically Ill Children
This grant explores how often and why mechanically ventilated children have mismatches between their own breathing efforts and the ventilator, with the goal of making ventilation safer and more comfortable for kids.
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Patient-ventilator asynchrony in critically ill children
A study to understand when ventilators don’t perfectly match a child’s breathing needs and how this affects recovery.
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Healthy Brain and Child Development: watching how kids grow from before birth to age 10
A large study across the US follows 7,200 mothers and their babies to understand how genes and early life experiences shape brain development.
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Targeting obesity to improve survival for children with ALL
A new approach explores whether reducing obesity-related factors can make chemotherapy work better for kids with acute lymphoblastic leukemia.
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TBL-1 and Wnt signaling in pediatric B- and T-cell ALL
A project explores whether blocking TBL-1 can make pediatric B- and T-cell acute lymphoblastic leukemia easier to treat, especially after relapse.
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In Vivo Look at Placental Blood Flow in Gestational Diabetes
A non-invasive MRI study in pregnant people with gestational diabetes and those without will map how placental blood vessels work and relate to baby outcomes.
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Fasting-mimicking diet and cancer stem cells in Wilms tumor
Aiming to see if a fasting-mimicking diet can boost cancer-killing treatment while protecting healthy cells in children with Wilms tumor.
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National Spina Bifida Patient Registry at Children's Hospital Los Angeles
Collects health, treatment, and outcome information from people with spina bifida cared for at CHLA to help improve care and quality of life.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Brain and Cognitive Development in Passed Prenatal Alcohol Exposure: How Prenatal Drinking Shapes Youth
A study following children born to mothers who drank during pregnancy to understand how prenatal alcohol exposure affects their brain and thinking abilities as they grow.
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Protecting kidney health in young children with spina bifida through standardized urology care
This project will use a standard urology care plan for young children with spina bifida to help keep their kidneys healthy and reduce urinary problems.
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Understanding how tumor particles prepare distant sites for cancer spread
This research looks at tiny tumor particles that travel through the body and may help scientists find ways to stop cancer from spreading.
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Brain blood flow and oxygen use in adult iron deficiency anemia
This study looks at how moderate iron deficiency anemia in adults affects brain blood flow, oxygen use, and thinking abilities, and whether iron treatment can reverse any problems.
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Understanding how premalignant retinoblastoma lesions form and progress in children
Researchers are studying how early retinal lesions in kids with RB1 loss become malignant, with the goal of finding ways to prevent retinoblastoma progression.
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Aqueous humor liquid biopsy to guide prognosis and monitoring in children with retinoblastoma
A liquid test using a small amount of eye fluid could reveal important tumor details to help predict how retinoblastoma in young children will behave and how well treatment is working.
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Neurodiagnostic and Omics Study of Down Syndrome Regression Disorder
A five-year study will look at brain signals, proteins, and immune markers to understand why some people with Down syndrome develop sudden neuropsychiatric symptoms.
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How prenatal alcohol exposure affects children's brain development and thinking
This project looks at how drinking during pregnancy relates to brain scans, thinking skills, and facial features in children and teens from the PASS birth cohort.
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Early use of semaglutide after weight-loss surgery in teens and young adults
A trial tests starting the obesity drug semaglutide soon after bariatric surgery in teens and young adults to help keep weight off.
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Brain and health tracking for children at Children's Hospital Los Angeles
This project follows thousands of children over many years to learn how their brains, behavior, and health change from late childhood into young adulthood.
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FOXR2 and ETS factors in a pediatric brain cancer: how they drive deadly DMGs
A study in kids with diffuse midline gliomas looks at how a FOXR2 gene and ETS transcription factors work together to fuel tumor growth, with the goal of finding new ways to stop it.
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How podocytes get damaged in Alport syndrome and how to protect them
A clinician-science team at a children’s hospital is studying why kidney filtering cells called podocytes fail in Alport syndrome and how to keep them healthy.
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How inflammation in pregnancy can affect a baby's brain protective barrier
This project looks at whether inflammation in pregnancy weakens a developing baby's blood-brain barrier and leads to lasting brain changes in the offspring.
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How uveal melanoma cells send signals that help them spread
This project follows adults with uveal melanoma and tracks signals in eye fluid and blood to find early signs that the cancer may be spreading.
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Treating teen depression by targeting sleep and the body clock
This project offers a sleep- and circadian-focused therapy for teens (ages 12–20) with major depression who tend to stay up late.
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Understanding how brain signals control fear extinction in PTSD
Researchers are studying how brain signals influence the way people stop fearing things that aren’t dangerous anymore, with the goal of helping those with PTSD.
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Patient-ventilator mismatch in critically ill children
This grant explores how children on ventilators sometimes fight against the machine, and aims to make ventilation more synchronized and safer.
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CHD7 gene and CHARGE links to heart and facial lymphatic development
Aimed at understanding how CHD7 gene changes affect the growth of heart and facial lymphatic vessels in model systems, with potential implications for CHARGE syndrome patients.
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Tracking children's brain and health at Children's Hospital Los Angeles
Following kids from late childhood through young adulthood to learn how their brains, behavior, and health change over time.
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Brain scans to predict and prevent CAR‑T related brain injury in children with B‑ALL
This project uses brain imaging to find signs that predict and help prevent brain side effects after CD19 CAR‑T therapy for children with relapsed or refractory B‑cell acute lymphoblastic leukemia.
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Identifying How Childhood Stress Affects Health and What Could Help
This study looks at how early life adversity affects young people and seeks biological clues to identify and prevent toxic stress.
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Predicting whether a child will die within one hour after withdrawing breathing support
This project uses a computer model to help doctors predict if a child will pass away within one hour after breathing support is removed, to guide organ donation decisions.
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How type 2 diabetes develops in teens
This project follows teenagers at risk for type 2 diabetes through puberty to track blood sugar, insulin, and lifestyle changes.
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Opioid use and long-term health in hospitalized infants
This project looks at whether how much and what types of opioids hospitalized infants receive relate to their brain development and later healthcare needs.
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Extra 17q chromosome and aggressive neuroblastoma
Researchers are looking at how an extra copy of chromosome 17q makes neuroblastoma tumors grow faster and resist chemotherapy in children.
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