Opioid use and long-term health in hospitalized infants
Official title: The Impact of Opioids on Health Outcomes for Hospitalized Infants
Funded at Children's Hospital of Los Angeles · NIH-11283969 · Data updated 2026-11-12
This project looks at whether how much and what types of opioids hospitalized infants receive relate to their brain development and later healthcare needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $590,678 |
| NIH project number | 5R01HD105656-05 |
| Project ID | NIH-11283969 on NIH RePORTER |
Who could benefit from this research
✓Could help
The focus is on critically ill infants hospitalized in neonatal or pediatric units whose records are included in the Pediatric Health Information System or the California Perinatal Quality Care Collaborative and who have linked long-term outcome data.
✕Less likely to help
Babies who were never hospitalized, whose medical records are not in the included databases, or who lack linked follow-up data would not be included and would not directly benefit from this analysis.
What this research studies
If your baby was hospitalized as a newborn or infant, researchers will link hospital records with a California follow-up database to build a large combined dataset. They will measure cumulative opioid dosing and types of opioid medicines given in the hospital and compare those exposures to later neurodevelopmental outcomes and healthcare use. By pooling data from many hospitals, the team aims to identify patterns in opioid prescribing that relate to developmental problems or higher future health costs. This is a retrospective study using existing records to find associations between past opioid exposure and long-term outcomes.
Why it matters
Potential benefit: Results could help doctors choose safer pain treatments for hospitalized infants to lower the risk of developmental issues and reduce future healthcare needs.
How similar studies have gone: Some smaller single-center and observational studies have suggested links between neonatal opioid exposure and later problems, but large multicenter linked datasets like this are relatively new.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Kelley-Quon, Lorraine I — Children's Hospital of Los Angeles
- Study coordinator: Kelley-Quon, Lorraine I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.