Exploring how gut bacteria affect nerve damage in diabetes

Who could benefit from this research

What this research studies

This research investigates the role of gut-derived extracellular vesicles in the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes. By analyzing how changes in gut bacteria influence nerve health, the study aims to uncover new therapeutic approaches. The researchers will focus on Lactobacillus-derived extracellular vesicles, which have shown promise in reducing inflammation and protecting nerves in preliminary studies. Patients may benefit from insights into how gut health impacts nerve damage and potential new treatments.

Why it matters

Where this research is happening

• Henry Ford Health + Michigan State University Health Sciences
  East Lansing, United States Active

Researchers

• Principal investigator: Liu, Xianshuang — Henry Ford Health + Michigan State University Health Sciences
• Study coordinator: Liu, Xianshuang

Related research

Other NIH-funded projects on the same topics.

• Gut bacterial vesicles and diabetic nerve damage

  This work looks at whether tiny particles released by gut bacteria can protect nerves and ease numbness and pain in people with diabetic peripheral neuropathy.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11286790

• Restoring sensation in amputated limbs for veterans with diabetic neuropathy

  This study is looking to help veterans who have lost lower limbs due to diabetic peripheral neuropathy by using special electrodes to create sensations that feel like they're coming from their missing foot, which could improve their daily activities and overall limb health.

  NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11262790

• Wearable vibration to improve movement and reduce pain in diabetic nerve damage

  A wearable vibration device is tested for four weeks to help adults with diabetic peripheral neuropathy walk better and experience less pain.

  NIH research University of Florida · Gainesville, United States · NIH-11226229

• Improving walking and reducing foot pressure for people with diabetic nerve damage

  This project tries real-time biofeedback to change how adults with diabetic peripheral neuropathy walk so they have lower harmful foot pressure and better walking speed.

  NIH research Florida Institu /human/machine Cognition · Pensacola, United States · NIH-11168786

• Investigating how tau phosphorylation affects nerve damage in diabetes

  This study is looking into how problems with insulin and a protein called tau affect nerve health in people with Type 1 Diabetes, with the hope of finding new ways to ease the pain and improve life for those dealing with diabetic nerve issues.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10980022

• New treatment for painful diabetic nerve damage using cannabidiol and palmitoylethanolamide tablets

  This study is testing a new type of tablet that combines two ingredients to help relieve pain for people with painful diabetic peripheral neuropathy, aiming to provide relief without the side effects of regular pain medications.

  NIH research Pure Green Pharmaceuticals, INC. · West Bloomfield, United States · NIH-10932267

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.