Exploring how gut bacteria affect nerve damage in diabetes
Investigating the role of gut extracellular vesicles in diabetic peripheral neuropathy
['FUNDING_R01'] · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · NIH-11046549
This study is looking at how tiny particles from gut bacteria might help protect nerves in people with diabetic peripheral neuropathy, which is a common issue for those with diabetes, and it hopes to find new ways to improve nerve health through better gut health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-11046549 on ClinicalTrials.gov |
What this research studies
This research investigates the role of gut-derived extracellular vesicles in the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes. By analyzing how changes in gut bacteria influence nerve health, the study aims to uncover new therapeutic approaches. The researchers will focus on Lactobacillus-derived extracellular vesicles, which have shown promise in reducing inflammation and protecting nerves in preliminary studies. Patients may benefit from insights into how gut health impacts nerve damage and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing symptoms of peripheral neuropathy.
Not a fit: Patients without diabetes or those who do not have symptoms of peripheral neuropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate nerve damage in diabetic patients.
How similar studies have performed: While the specific approach of using gut-derived extracellular vesicles in DPN is novel, similar studies have shown promise in other conditions related to gut health and inflammation.
Where this research is happening
EAST LANSING, UNITED STATES
- HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, XIANSHUANG — HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES
- Study coordinator: LIU, XIANSHUANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.