Investigating how tau phosphorylation affects nerve damage in diabetes
Official title: The Role of Tau Phosphorylation in Diabetic Peripheral Neuropathy
Funded at University of Tx Md Anderson Can Ctr · NIH-10980022 · Data updated 2026-11-12
This study is looking into how problems with insulin and a protein called tau affect nerve health in people with Type 1 Diabetes, with the hope of finding new ways to ease the pain and improve life for those dealing with diabetic nerve issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $207,960 |
| NIH project number | 1K99DK142197-01A1 |
| Project ID | NIH-10980022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes Mellitus who are experiencing symptoms of diabetic peripheral neuropathy.
✕Less likely to help
Patients without diabetes or those with other forms of neuropathy unrelated to diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind diabetic peripheral neuropathy, a painful condition affecting many individuals with diabetes. The study will explore how insulin dysregulation and tau phosphorylation contribute to nerve dysfunction in patients with Type 1 Diabetes Mellitus (T1DM). Using advanced techniques like high content microscopy and specific inhibitors, researchers aim to identify changes in tau levels and their impact on nerve health. The ultimate goal is to develop new therapeutic strategies that could alleviate symptoms and improve quality of life for those affected.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce pain and improve nerve function in patients with diabetic peripheral neuropathy.
How similar studies have gone: Previous research has shown promising results in understanding the role of tau phosphorylation in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Nichols, James M — University of Tx Md Anderson Can Ctr
- Study coordinator: Nichols, James M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.