New treatment for painful diabetic nerve damage using cannabidiol and palmitoylethanolamide tablets
Official title: Cannabidiol/Palmitoylethanolamide sublingual tablets for the treatment of Painful Diabetic Peripheral Neuropathy
Funded at Pure Green Pharmaceuticals, INC. · NIH-10932267 · Data updated 2026-11-12
This study is testing a new type of tablet that combines two ingredients to help relieve pain for people with painful diabetic peripheral neuropathy, aiming to provide relief without the side effects of regular pain medications.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pure Green Pharmaceuticals, INC. NIH-funded |
| Lab location | 1 site (West Bloomfield, United States) |
| Project start | September 20, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $932,613 |
| NIH project number | 5R44DK136492-02 |
| Project ID | NIH-10932267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with painful diabetic peripheral neuropathy who are seeking alternative pain relief options.
✕Less likely to help
Patients who do not have diabetic peripheral neuropathy or those who are not diabetic may not benefit from this research.
What this research studies
This research investigates a novel treatment for painful diabetic peripheral neuropathy (pDPN) using sublingual tablets that combine cannabidiol and palmitoylethanolamide. The approach aims to provide effective pain relief by targeting multiple pain pathways without the adverse effects commonly associated with traditional pain medications. Patients will take these tablets under supervision to assess their effectiveness and safety in alleviating symptoms of pDPN. The study seeks to fill a significant gap in treatment options for this debilitating condition.
Why it matters
Potential benefit: If successful, this research could offer a safer and more effective pain management option for patients suffering from painful diabetic peripheral neuropathy.
How similar studies have gone: While there have been limited advancements in neuropathic pain treatments, this specific combination of cannabidiol and palmitoylethanolamide represents a novel approach that has not been widely tested in clinical settings.
Where this research is happening
-
Pure Green Pharmaceuticals, INC.
West Bloomfield, United States Active
Researchers
- Principal investigator: Kimless, Debra — Pure Green Pharmaceuticals, INC.
- Study coordinator: Kimless, Debra
Related research
Other NIH-funded projects on the same topics.
-
Gut bacterial vesicles and diabetic nerve damage
This work looks at whether tiny particles released by gut bacteria can protect nerves and ease numbness and pain in people with diabetic peripheral neuropathy.
-
Restoring sensation in amputated limbs for veterans with diabetic neuropathy
This study is looking to help veterans who have lost lower limbs due to diabetic peripheral neuropathy by using special electrodes to create sensations that feel like they're coming from their missing foot, which could improve their daily activities and overall limb health.
-
Wearable vibration to improve movement and reduce pain in diabetic nerve damage
A wearable vibration device is tested for four weeks to help adults with diabetic peripheral neuropathy walk better and experience less pain.
-
Improving walking and reducing foot pressure for people with diabetic nerve damage
This project tries real-time biofeedback to change how adults with diabetic peripheral neuropathy walk so they have lower harmful foot pressure and better walking speed.
-
Exploring how gut bacteria affect nerve damage in diabetes
This study is looking at how tiny particles from gut bacteria might help protect nerves in people with diabetic peripheral neuropathy, which is a common issue for those with diabetes, and it hopes to find new ways to improve nerve health through better gut health.
-
Investigating how tau phosphorylation affects nerve damage in diabetes
This study is looking into how problems with insulin and a protein called tau affect nerve health in people with Type 1 Diabetes, with the hope of finding new ways to ease the pain and improve life for those dealing with diabetic nerve issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.