New treatment for painful diabetic nerve damage using cannabidiol and palmitoylethanolamide tablets

Cannabidiol/Palmitoylethanolamide sublingual tablets for the treatment of Painful Diabetic Peripheral Neuropathy

NIH-funded research Pure Green Pharmaceuticals, INC. · NIH-10932267

This study is testing a new type of tablet that combines two ingredients to help relieve pain for people with painful diabetic peripheral neuropathy, aiming to provide relief without the side effects of regular pain medications.

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionPure Green Pharmaceuticals, INC. NIH-funded
Lab location1 site (West Bloomfield, United States)
Project IDNIH-10932267 on NIH RePORTER

What this research studies

This research investigates a novel treatment for painful diabetic peripheral neuropathy (pDPN) using sublingual tablets that combine cannabidiol and palmitoylethanolamide. The approach aims to provide effective pain relief by targeting multiple pain pathways without the adverse effects commonly associated with traditional pain medications. Patients will take these tablets under supervision to assess their effectiveness and safety in alleviating symptoms of pDPN. The study seeks to fill a significant gap in treatment options for this debilitating condition.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with painful diabetic peripheral neuropathy who are seeking alternative pain relief options.

Not a fit: Patients who do not have diabetic peripheral neuropathy or those who are not diabetic may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could offer a safer and more effective pain management option for patients suffering from painful diabetic peripheral neuropathy.

How similar studies have performed: While there have been limited advancements in neuropathic pain treatments, this specific combination of cannabidiol and palmitoylethanolamide represents a novel approach that has not been widely tested in clinical settings.

Where this research is happening

West Bloomfield, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.