Rapid, multi-drug initiation for people with CKD and type 2 diabetes
Official title: A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKD
Funded at Baylor Research Institute · NIH-11343746 · Data updated 2026-11-12
A small study will try starting several key diabetes and kidney medicines at the same time in adults with CKD and type 2 diabetes to see if this fast plan is safe and helpful.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor Research Institute NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 1, 2026 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $306,441 |
| NIH project number | 1R01DK147678-01 |
| Project ID | NIH-11343746 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease and type 2 diabetes who are candidates for multiple guideline-recommended therapies.
✕Less likely to help
Patients who cannot tolerate multiple medications or have specific contraindications may not benefit.
What this research studies
This project tests whether starting several medicines together within 8 weeks is safe and doable for adults with CKD and type 2 diabetes. It will track safety signals and early effectiveness, focusing on kidney and heart health as well as medication adherence. The study uses a randomized design to compare rapid, simultaneous therapy initiation against usual care. If successful, it could show a new, practical way to reduce cardio-kidney risk sooner for patients. The team will monitor adverse events and collect data on health outcomes to guide future care.
Why it matters
Potential benefit: If the approach proves safe and effective, patients could receive faster protection against cardiovascular and kidney complications.
How similar studies have gone: Previous trials suggest combined therapy can be more effective, but rapid, simultaneous initiation in CKD with diabetes is being explored.
Where this research is happening
-
Baylor Research Institute
Dallas, United States Active
Researchers
- Principal investigator: Khan, Mohammad Shahzeb — Baylor Research Institute
- Study coordinator: Khan, Mohammad Shahzeb
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.