Stronger bones for people with both diabetes and chronic kidney disease
Official title: Improving bone mass and quality in comorbid diabetes and chronic kidney disease
Funded at Rlr VA Medical Center · NIH-11264814 · Data updated 2026-11-12
This work tests whether combining treatments that build bone mass and improve bone quality can make bones stronger for people who have both diabetes and chronic kidney disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rlr VA Medical Center NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| NIH project number | 5I01BX005990-04 |
| Project ID | NIH-11264814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Eventually, people who have both diabetes and chronic kidney disease—especially those with weakened bones or a history of fractures—would be the likely candidates for related clinical trials.
✕Less likely to help
People who do not have both diabetes and chronic kidney disease, or whose bone problems are caused by unrelated conditions, may not benefit from the specific treatments tested here.
What this research studies
From a patient viewpoint, the team created a new animal model that mimics having both diabetes and chronic kidney disease so they can study how the two conditions together harm bones. They will give combinations of therapies aimed at increasing bone mass and improving the microscopic quality of bone tissue. The researchers will measure bone strength and fracture resistance to see which combinations restore mechanical strength. The goal is to find treatments that could be moved into human trials to reduce fracture risk in people with these two conditions.
Why it matters
Potential benefit: If successful, this could lead to combined treatments that make bones less likely to break and reduce fractures and fracture-related complications in people with diabetes and chronic kidney disease.
How similar studies have gone: Existing therapies can improve either bone mass or bone quality separately, but combining therapies specifically for diabetes plus CKD is largely novel and not well tested.
Where this research is happening
-
Rlr VA Medical Center
Indianapolis, United States Active
Researchers
- Principal investigator: Wallace, Joseph Michael — Rlr VA Medical Center
- Study coordinator: Wallace, Joseph Michael
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Improving bone health in patients with diabetes and chronic kidney disease
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.