Improving bone health in patients with diabetes and chronic kidney disease

Who could benefit from this research

What this research studies

This research investigates how diabetes and chronic kidney disease (CKD) affect bone health, particularly focusing on the risk of fractures. It aims to understand the interactions between these two conditions and their combined impact on bone mass and quality. By using a novel animal model that simulates both diseases, the research will explore effective treatments that can enhance bone strength and reduce fracture risk. The ultimate goal is to develop therapies that can improve skeletal health in patients suffering from both diabetes and CKD.

Why it matters

Where this research is happening

• Rlr VA Medical Center
  Indianapolis, United States Active

Researchers

• Principal investigator: Wallace, Joseph Michael — Rlr VA Medical Center
• Study coordinator: Wallace, Joseph Michael

Related research

Other NIH-funded projects on the same topics.

• Unrecognized Primary Aldosteronism and Kidney Disease in Diabetes

  A study at Brigham and Women’s Hospital will explore whether unrecognized primary aldosteronism contributes to kidney disease and heart risk in people with diabetes.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11349753

• Rapid, multi-drug initiation for people with CKD and type 2 diabetes

  A small study will try starting several key diabetes and kidney medicines at the same time in adults with CKD and type 2 diabetes to see if this fast plan is safe and helpful.

  NIH research Baylor Research Institute · Dallas, United States · NIH-11343746

• Improving heart- and kidney-protective treatment for people with type 2 diabetes and chronic kidney disease

  This project will help people with type 2 diabetes and chronic kidney disease get proven medicines that protect the heart and kidneys but are often missed.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11303260

• Stronger bones for people with both diabetes and chronic kidney disease

  This work tests whether combining treatments that build bone mass and improve bone quality can make bones stronger for people who have both diabetes and chronic kidney disease.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11264814

• Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes

  This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11190882

• Plant-Focused Eating for Diabetes and Kidney Disease

  This research explores if a plant-focused eating plan can help people with both diabetes and chronic kidney disease manage their health.

  NIH research Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, United States · NIH-11160524

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.