PAR1’s role in lung lymphatics and a new therapy approach for ARDS
Official title: Identifying Novel Roles and the Therapeutic Potential of the Thrombin Receptor Protease Activated Receptor-1 (PAR1) in Lung Lymphatic Function and Acute Respiratory Distress Syndrome
Funded at Weill Medical Coll of Cornell Univ · NIH-11412416 · Data updated 2026-11-12
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $750,280 |
| NIH project number | 5R01HL179084-02 |
| Project ID | NIH-11412416 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for ARDS or acute lung injury who may participate in future translational studies or trials related to PAR1-based therapies.
✕Less likely to help
Patients without ARDS or related lung injury may not benefit from this specific PAR1-focused research.
What this research studies
ARDS is a severe lung condition with high mortality. The research uses mouse models to study how PAR1 influences lymphatic vessels in the lung, which helps control inflammation and fluid drainage. By uncovering new ways PAR1 functions in the lymphatic system, the project aims to identify potential therapeutic targets to prevent or lessen lung injury in ARDS. The work could pave the way for treatments that modulate coagulation and immune responses in patients with acute lung injury.
Why it matters
Potential benefit: If successful, the research could reveal new targets for therapies to reduce lung injury and improve survival in ARDS patients.
How similar studies have gone: Previous work shows PAR1 is involved in inflammation and coagulation in ARDS, but the lymphatic angle is a novel approach with potential for meaningful impact.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Reed, Hasina Outtz — Weill Medical Coll of Cornell Univ
- Study coordinator: Reed, Hasina Outtz
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.