Immune, hormone, and muscle energy links to recovery after ARDS
Official title: Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors
Funded at Columbia University Health Sciences · NIH-11402596 · Data updated 2026-11-12
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $694,344 |
| NIH project number | 5R01HL164777-04 |
| Project ID | NIH-11402596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) who survived ARDS and are being followed after hospital discharge, with ongoing or potential physical impairment.
✕Less likely to help
Patients without persistent physical disability or those not eligible for the 12-month follow-up may see limited direct benefit.
What this research studies
This research follows ARDS survivors after they leave the hospital to see how inflammation, hormones, and muscle mitochondria affect physical recovery over a year. It enrolls 345 ARDS survivors at discharge and does a focused 3-month in-person study of 180 participants to identify those not yet recovered from disability. The study uses blood tests and muscle assessments to explore potential treatment targets that could improve strength and function. By understanding which biological factors stay dysregulated, the team hopes to guide therapies that help patients regain mobility and independence.
Why it matters
Potential benefit: If successful, findings could point to new ways to enhance muscle strength and physical recovery for ARDS survivors.
How similar studies have gone: Past work has shown that systemic factors and muscle energetics relate to recovery, but precise targets for ARDS recovery remain to be proven.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Baldwin, Matthew R — Columbia University Health Sciences
- Study coordinator: Baldwin, Matthew R
Related research
Other NIH-funded projects on the same topics.
-
Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
-
Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
-
PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
-
Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
-
Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
-
Imaging the Pulmonary Circulation to Personalize ARDS Care
A patient-focused look at using advanced imaging to understand lung blood flow in ARDS so doctors can tailor treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.