Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
Official title: Identifying Patients who Benefit from Paralytics in Acute Respiratory Distress Syndrome Using High-Frequency Clinical Data
Funded at University of Michigan at Ann Arbor · NIH-11432547 · Data updated 2026-11-12
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $169,560 |
| NIH project number | 1K08HL189306-01 |
| Project ID | NIH-11432547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acute respiratory distress syndrome who are mechanically ventilated and considered for paralytic medications.
✕Less likely to help
Patients not receiving paralytics or those without ARDS may not be directly affected by this research.
What this research studies
Dr. Barker’s program will use advanced data analysis to personalize how paralysis is used during mechanical ventilation for ARDS patients. The project blends clinical care with computational methods to learn which patterns in real-time monitoring and health records predict benefit from paralytics. Training occurs within the University of Michigan’s Pulmonary and Critical Care pathway, under a team of experts in data science, signal processing, and causal inference. The goal is to equip clinicians with tools and knowledge to tailor paralytic use to individual patients.
Why it matters
Potential benefit: If successful, clinicians could more accurately identify which ARDS patients will benefit from paralytics, potentially improving outcomes and reducing unnecessary exposure.
How similar studies have gone: Prior work in ARDS and data-driven ventilation strategies has shown promise, but this project focuses on predicting paralytic benefit using high-frequency data.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Barker, Anna Kathryn — University of Michigan at Ann Arbor
- Study coordinator: Barker, Anna Kathryn
Related research
Other NIH-funded projects on the same topics.
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Resilience endotypes and early ARDS detection using biomarkers and AI
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This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
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Imaging the Pulmonary Circulation to Personalize ARDS Care
A patient-focused look at using advanced imaging to understand lung blood flow in ARDS so doctors can tailor treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.