Understanding immune checkpoints in acute respiratory distress syndrome
Immune Checkpoints in Acute Respiratory Distress Syndrome (IC-ARDS)
This study is looking at how certain immune pathways might affect people with acute respiratory distress syndrome (ARDS) to help create better treatment options and improve care for patients who need long-term breathing support.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10871697 on NIH RePORTER |
What this research studies
This research investigates the role of immune checkpoints, specifically the PD-1 and PD-L1 pathways, in patients suffering from acute respiratory distress syndrome (ARDS). By examining how these pathways affect immune function and inflammation in ARDS patients, the study aims to develop more personalized prognostic and therapeutic approaches. The research will analyze the expression of PD-L1 on alveolar macrophages and its relationship with prolonged mechanical ventilation in ARDS patients. This could lead to better management strategies for those affected by this severe condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome, particularly those requiring mechanical ventilation.
Not a fit: Patients with chronic respiratory conditions or those not experiencing acute respiratory distress syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with acute respiratory distress syndrome.
How similar studies have performed: Previous research has shown promising results in understanding immune checkpoints in other conditions, suggesting potential for success in this area as well.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Mikacenic, Carmen R — Benaroya Research Inst at Virginia Mason
- Study coordinator: Mikacenic, Carmen R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.