Understanding immune checkpoints in acute respiratory distress syndrome

Who could benefit from this research

What this research studies

This research investigates the role of immune checkpoints, specifically the PD-1 and PD-L1 pathways, in patients suffering from acute respiratory distress syndrome (ARDS). By examining how these pathways affect immune function and inflammation in ARDS patients, the study aims to develop more personalized prognostic and therapeutic approaches. The research will analyze the expression of PD-L1 on alveolar macrophages and its relationship with prolonged mechanical ventilation in ARDS patients. This could lead to better management strategies for those affected by this severe condition.

Why it matters

Where this research is happening

• Benaroya Research Inst at Virginia Mason
  Seattle, United States Active

Researchers

• Principal investigator: Mikacenic, Carmen R — Benaroya Research Inst at Virginia Mason
• Study coordinator: Mikacenic, Carmen R

Related research

Other NIH-funded projects on the same topics.

• Resilience endotypes and early ARDS detection using biomarkers and AI

  A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.

  NIH research Duke University · Durham, United States · NIH-11416345

• A new treatment using gut microbiome to help patients with severe lung injury from viruses

  This study is exploring a new way to help people with acute respiratory distress syndrome (ARDS) from viral infections by looking at how certain immune cells and gut bacteria can work together to reduce inflammation and improve recovery.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10764911

• Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data

  This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11432547

• PAR1’s role in lung lymphatics and a new therapy approach for ARDS

  This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11412416

• Dead space and inhaled nitric oxide in pediatric ARDS

  This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11411416

• Immune, hormone, and muscle energy links to recovery after ARDS

  This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>

  NIH research Columbia University Health Sciences · New York, United States · NIH-11402596

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.