Pulmonary rehabilitation to reduce breathing problems after TB
Official title: TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity
Funded at Johns Hopkins University · NIH-11418526 · Data updated 2026-11-12
A program of supervised breathing and exercise therapy is tested to see if it helps people who have recovered from tuberculosis breathe better and feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $446,971 |
| NIH project number | 5R01AI169588-04 |
| Project ID | NIH-11418526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of tuberculosis and persistent lung impairment who can participate in a rehabilitation program.
✕Less likely to help
Individuals without post-TB lung impairment or those unable to attend rehabilitation sessions may not benefit.
What this research studies
TB can leave lasting lung problems even after treatment. This project tests a pulmonary rehabilitation program in India to see if it reduces breathing trouble, improves daily functioning, and is cost-effective. The study will measure how well the program works, how feasible it is to deliver in routine care, and whether it provides good value for healthcare systems. Findings could influence care for TB survivors in high-burden settings and potentially in the US where TB cases persist.
Why it matters
Potential benefit: If successful, TB survivors could experience better lung function and quality of life through a practical rehab program integrated into standard care.
How similar studies have gone: Prior research shows pulmonary rehabilitation helps people with chronic lung disease, but its effect specifically on post-TB respiratory morbidity is not yet established.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
Related research
Other NIH-funded projects on the same topics.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
-
Pulmonary rehabilitation to prevent post-TB lung problems
This project offers and compares two home-based breathing and exercise programs for adults with TB to help prevent long-term lung problems after treatment.
-
Pulmonary rehabilitation to prevent lung problems after tuberculosis
Two home-based breathing and exercise programs are offered to adults being treated for tuberculosis to help protect lung health after treatment.
-
Pulmonary rehabilitation to prevent lung problems after tuberculosis
This project compares two home-based breathing and exercise programs given during TB treatment to help adults prevent long-term lung problems after pulmonary tuberculosis.
-
Improving lung health for people recovering from tuberculosis
This study is looking at two different home exercise programs to help people who have finished tuberculosis treatment breathe better and feel healthier, while also making sure these programs are easy to use and affordable for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.