Pulmonary rehabilitation to prevent lung problems after tuberculosis
Official title: TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity
Funded at Johns Hopkins University · NIH-11415440 · Data updated 2026-11-12
Two home-based breathing and exercise programs are offered to adults being treated for tuberculosis to help protect lung health after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $94,312 |
| NIH project number | 3R01AI169588-03S1 |
| Project ID | NIH-11415440 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) currently receiving TB treatment who can perform light exercise and are willing to follow a home-based rehabilitation program are the ideal candidates.
✕Less likely to help
People under 21, those who are too sick to do the exercises, or those with other severe medical conditions may not receive benefit from these programs.
What this research studies
If you are an adult receiving TB treatment, you may be offered one of two home-based pulmonary rehabilitation programs that combine aerobic exercise, breathing techniques, and coach support during treatment. The project will compare how well each program prevents lung problems after TB by measuring breathing, symptoms, and daily activity following treatment. Researchers will also examine clinic organization, how closely coaches deliver the programs, and how patients follow the exercises. Costs and budget impact will be compared to determine which approach is most affordable and scalable in resource-limited settings.
Why it matters
Potential benefit: If successful, these programs could reduce long-term lung damage and improve breathing and daily quality of life for people who survive TB.
How similar studies have gone: Pulmonary rehabilitation has helped people with chronic lung diseases like COPD, but applying home-based PR during TB treatment to prevent post-TB lung problems is largely new and unproven.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
Related research
Other NIH-funded projects on the same topics.
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Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
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Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
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Pulmonary rehabilitation to reduce breathing problems after TB
A program of supervised breathing and exercise therapy is tested to see if it helps people who have recovered from tuberculosis breathe better and feel better.
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Pulmonary rehabilitation to prevent post-TB lung problems
This project offers and compares two home-based breathing and exercise programs for adults with TB to help prevent long-term lung problems after treatment.
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Pulmonary rehabilitation to prevent lung problems after tuberculosis
This project compares two home-based breathing and exercise programs given during TB treatment to help adults prevent long-term lung problems after pulmonary tuberculosis.
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Improving lung health for people recovering from tuberculosis
This study is looking at two different home exercise programs to help people who have finished tuberculosis treatment breathe better and feel healthier, while also making sure these programs are easy to use and affordable for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.