Pulmonary rehabilitation to prevent lung problems after tuberculosis
TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity
This project compares two home-based breathing and exercise programs given during TB treatment to help adults prevent long-term lung problems after pulmonary tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11167676 on NIH RePORTER |
What this research studies
If you have pulmonary tuberculosis, this trial compares two different home-based pulmonary rehabilitation programs (and usual care) started during TB treatment to see which best prevents lasting lung damage. Participants will follow structured aerobic and breathing exercises, receive behavioral coaching, and get clinic support delivered by trained coaches. The team will measure lung function, symptoms, physical capacity, adherence, and costs, while also looking at how clinics organize care and how faithfully coaches deliver the programs. The study is carried out in India to test feasibility and cost-effectiveness in settings where many TB survivors live.
Who could benefit from this research
Good fit: Adults currently receiving treatment for pulmonary tuberculosis, especially those able to do home-based exercise and coaching, are the ideal candidates.
Not a fit: People without recent or active pulmonary TB, or those who cannot safely perform exercise because of other health issues, are unlikely to get direct benefit.
Why it matters
Potential benefit: If successful, these programs could reduce long-term breathing problems and improve daily function for people who had TB.
How similar studies have performed: Pulmonary rehabilitation has helped people with other chronic lung diseases, but using it during TB treatment to prevent post-TB lung problems is relatively new and not yet proven.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.