Pulmonary rehabilitation to prevent lung problems after tuberculosis
Official title: TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity
Funded at Johns Hopkins University · NIH-11167676 · Data updated 2026-11-12
This project compares two home-based breathing and exercise programs given during TB treatment to help adults prevent long-term lung problems after pulmonary tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $430,078 |
| NIH project number | 5R01AI169588-03 |
| Project ID | NIH-11167676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults currently receiving treatment for pulmonary tuberculosis, especially those able to do home-based exercise and coaching, are the ideal candidates.
✕Less likely to help
People without recent or active pulmonary TB, or those who cannot safely perform exercise because of other health issues, are unlikely to get direct benefit.
What this research studies
If you have pulmonary tuberculosis, this trial compares two different home-based pulmonary rehabilitation programs (and usual care) started during TB treatment to see which best prevents lasting lung damage. Participants will follow structured aerobic and breathing exercises, receive behavioral coaching, and get clinic support delivered by trained coaches. The team will measure lung function, symptoms, physical capacity, adherence, and costs, while also looking at how clinics organize care and how faithfully coaches deliver the programs. The study is carried out in India to test feasibility and cost-effectiveness in settings where many TB survivors live.
Why it matters
Potential benefit: If successful, these programs could reduce long-term breathing problems and improve daily function for people who had TB.
How similar studies have gone: Pulmonary rehabilitation has helped people with other chronic lung diseases, but using it during TB treatment to prevent post-TB lung problems is relatively new and not yet proven.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
Related research
Other NIH-funded projects on the same topics.
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Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
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Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
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Pulmonary rehabilitation to reduce breathing problems after TB
A program of supervised breathing and exercise therapy is tested to see if it helps people who have recovered from tuberculosis breathe better and feel better.
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Pulmonary rehabilitation to prevent post-TB lung problems
This project offers and compares two home-based breathing and exercise programs for adults with TB to help prevent long-term lung problems after treatment.
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Pulmonary rehabilitation to prevent lung problems after tuberculosis
Two home-based breathing and exercise programs are offered to adults being treated for tuberculosis to help protect lung health after treatment.
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Improving lung health for people recovering from tuberculosis
This study is looking at two different home exercise programs to help people who have finished tuberculosis treatment breathe better and feel healthier, while also making sure these programs are easy to use and affordable for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.