Pulmonary rehabilitation to prevent post-TB lung problems
TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity
This project offers and compares two home-based breathing and exercise programs for adults with TB to help prevent long-term lung problems after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11416182 on NIH RePORTER |
What this research studies
If you are an adult receiving TB treatment, you could be enrolled in one of two home-based pulmonary rehabilitation programs that teach breathing exercises, aerobic activity, and self-care. Coaches will support you at home and clinics will track your symptoms, lung function, and ability to do daily activities over time. The study team will compare which program helps prevent lasting lung damage, how well coaches deliver the programs, and how patients adopt the exercises. Costs and budget impact of each approach will also be measured to see which option is most practical to scale.
Who could benefit from this research
Good fit: Adults aged 21 and older with active tuberculosis who can participate in home-based pulmonary rehabilitation while on TB treatment are the ideal candidates.
Not a fit: People under 21, those with unrelated severe disabilities that prevent home exercise, or patients whose lung problems are not related to TB may not receive benefit from these programs.
Why it matters
Potential benefit: If successful, this could lower the risk of lasting breathing problems and improve quality of life for people treated for TB.
How similar studies have performed: Pulmonary rehabilitation is effective for other chronic lung diseases, but using home-based PR during TB treatment to prevent post-TB lung problems is a newer approach that has not been widely tested.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.