Pulmonary rehabilitation to prevent post-TB lung problems
Official title: TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity
Funded at Johns Hopkins University · NIH-11416182 · Data updated 2026-11-12
This project offers and compares two home-based breathing and exercise programs for adults with TB to help prevent long-term lung problems after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $47,029 |
| NIH project number | 3R01AI169588-03S2 |
| Project ID | NIH-11416182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older with active tuberculosis who can participate in home-based pulmonary rehabilitation while on TB treatment are the ideal candidates.
✕Less likely to help
People under 21, those with unrelated severe disabilities that prevent home exercise, or patients whose lung problems are not related to TB may not receive benefit from these programs.
What this research studies
If you are an adult receiving TB treatment, you could be enrolled in one of two home-based pulmonary rehabilitation programs that teach breathing exercises, aerobic activity, and self-care. Coaches will support you at home and clinics will track your symptoms, lung function, and ability to do daily activities over time. The study team will compare which program helps prevent lasting lung damage, how well coaches deliver the programs, and how patients adopt the exercises. Costs and budget impact of each approach will also be measured to see which option is most practical to scale.
Why it matters
Potential benefit: If successful, this could lower the risk of lasting breathing problems and improve quality of life for people treated for TB.
How similar studies have gone: Pulmonary rehabilitation is effective for other chronic lung diseases, but using home-based PR during TB treatment to prevent post-TB lung problems is a newer approach that has not been widely tested.
Where this research is happening
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Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
Related research
Other NIH-funded projects on the same topics.
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Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
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Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
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Pulmonary rehabilitation to reduce breathing problems after TB
A program of supervised breathing and exercise therapy is tested to see if it helps people who have recovered from tuberculosis breathe better and feel better.
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Pulmonary rehabilitation to prevent lung problems after tuberculosis
Two home-based breathing and exercise programs are offered to adults being treated for tuberculosis to help protect lung health after treatment.
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Pulmonary rehabilitation to prevent lung problems after tuberculosis
This project compares two home-based breathing and exercise programs given during TB treatment to help adults prevent long-term lung problems after pulmonary tuberculosis.
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Improving lung health for people recovering from tuberculosis
This study is looking at two different home exercise programs to help people who have finished tuberculosis treatment breathe better and feel healthier, while also making sure these programs are easy to use and affordable for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.