How blood flow near carotid webs leads to clots and stroke
Official title: Determining the specific hemodynamics related to clot formation and subsequent stroke in subjects with carotid webs
Funded at Emory University · NIH-11306082 · Data updated 2026-11-12
Using CT angiograms and computer blood-flow models, researchers will study how blood moves around carotid webs in people to find why clots form and cause strokes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $242,495 |
| NIH project number | 5R21NS142808-02 |
| Project ID | NIH-11306082 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with a diagnosed carotid web, especially those who have had a stroke or clot seen on CT angiography, would be the best fit for contributing data or participating.
✕Less likely to help
People without a carotid web or whose strokes have a clearly different cause are unlikely to benefit from this work.
What this research studies
If I have a carotid web, this project will use CT angiography images from people who had clots on the web and when the clots were gone to build 3D artery models. The team will run computer simulations of blood flow (computational fluid dynamics) on those exact artery shapes to measure forces like shear rate where clots formed. They will combine cases from five centers to get a larger, more reliable set of examples. The goal is to find specific blood-flow values linked to clot formation so doctors can better decide who needs treatment.
Why it matters
Potential benefit: It could help doctors predict which carotid webs are likely to cause dangerous clots and guide decisions to prevent repeat strokes.
How similar studies have gone: Earlier small-scale computer-flow studies have suggested low shear near carotid webs promotes red clot formation, but those efforts were limited by sample size or simplified artery shapes, so this multi-center approach is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Oshinski, John N — Emory University
- Study coordinator: Oshinski, John N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.